on their affect on stem cells..in skin at least.
Phycojuvenine
is extracted from the brown seaweed
Laminaria digitata, also called oarweed,
or “fouet des sorcières” in France and
“Kombu” in Japan. Phycojuvenine acts
on adult stem cells in the dermis in three
steps. It restores ageing adult stem cells of
the dermis with their capacity for division,
thereby stimulating their action. It protects
adult stem cells from ageing by preserving
and prolonging their efficacy. It rejuvenates fibroblasts, stimulates collagen synthesis
in mature skin and erases wrinkles. INCI
name for Phycojuvenine G: Glycerin (and)
water (and) Laminaria digitata extract
http://www.personalcaremagazine.com/Sto ... Story=4940Initially, Phycojuvenine 1% significantly revitalises adult stem cells in mature skin (+28% compared to the control, Fig. 5) which recovers a cell vitality equivalent to that of young skin (95% vs 99%). It then has a protective action with respect to the factors of cell ageing such as UVB. From 1%, Phycojuvenine significantly protects the stem cells against ageing: +10% of cell vitality for young skin and +70% for aged skin (Fig. 6). This protective effect is more visible on aged skin and compensates for the weakening of the internal defence systems due to skin ageing.
Rejuvenating fibroblasts and collagen synthesis
Fibroblasts grow older and their age may be evaluated by observing their morphology (up to 7 different morphotypes may be counted). Phycojuvenine displaces the average age of fibroblasts subjected to an ageing process from morphotype V to morphotype II to III (Fig. 7). By rejuvenating adult stem cells and then by protecting them from ageing, Phycojuvenine has a rejuvenating effect on fibroblasts which then produce more collagen: +18% compared to aged fibroblast cultures without Phycojuvenine. Aged fibroblasts then synthesise similar quantities of collagen to young fibroblasts: 137% vs 150% (Fig..
Filling wrinkles
After 28 days of twice-daily use of 1% Phycojuvenine on crow’s foot wrinkles, 80% of volunteers observed a significant reduction in the main wrinkle of -6.2% on average and up to -15.6% (Fig. 9). This reduction in the depth of wrinkles was accompanied by a smoothing effect with a reduction in mean roughness of up to -29.6%. Phycojuvenine 1% rejuvenates ageing adult stem cells and protects them from ageing. By restoring their vitality and their capacity for division, 1% Phycojuvenine prolongs their efficacy. Dermal fibroblasts are rejuvenated, collagen synthesis of mature skin equals that of young skin, the skin is retightened, and wrinkles are filled and disappear.
‘Lasting’ and ‘controlled’ approach
Rather than force cell proliferation, Phycojuvenine and Phycosaccharide AI open the way to a “lasting” and “controlled” approach in the concept of stem cells, by optimising their mobilisation and rejuvenation in the dermis and epidermis. With Phycojuvenine and Phycosaccharide AI, older skin recovers a level of dermal and epidermal adult stem cells equivalent to that of young skin. Once the skin is rebuilt, wrinkles and lines are filled and smoothed.