New interview with Dr. Khadavi

Post by **HairLossFight.com** » Sun Oct 16, 2005 9:53 pm

http://www.morphollica.com/interviews/k ... ctober.php

October 16, 2005

Early in 2004 Morphollica.com interviewed Dr. Khadavi about hair loss and it's treatment. You can read the original interview here: Dr. Khadavi Interview (2004).

Dr. Khadavi revealed a lot of useful and interesting information in the interview last year, including some predictions for the future of hair loss treatment, so we decided to do a follow-up interview to get an update on what's happening at Revivogen, and whether Dr. Khadavi has any new information. Enjoy.

Morphollica.com: Dr. Khadavi, The last time we spoke you made some very optimistic predictions about follicular neogenenis in that you thought it could be available within 3 to 5 years. You mentioned that there were 4 laboratories working on it. Do you have any new information about the progress? Also, do you still think the timeline you mentioned is valid?

Dr. Khadavi: One of the four laboratories has been placed on suspension of trials since one of their patients in the trials had developed benign skin tumors called trichoepitheliomas. Although these tumors are not malignant, they signal that the production of the hair follicle with this method is not perfect. This has brought concerns to the FDA since there may be growth factors in the growth medium that may be stimulating the conversion of the follicular precursor cells into tumor producing cells. As far as I know there has not been a delay in the studies in the other three laboratories. Hopefully, we will have this technology available to us within the next 3-5 years.

Morphollica.com: Revivogen is already a well-known product and a popular one in the hair loss industry. Have you made any progress with the technology, with regards to new ingredients or changes to the formulation since last year?

Dr. Khadavi: From researching and testing other ingredients that could potentially be used in Revivogen, we are currently not adding any new ingredients. This is due to the fact that maximal inhibition of DHT has been achieved with the active ingredients of Revivogen since the active ingredients that are being used in the current Revivogen formula are the most potent of all the ingredients available to us that are natural. Additionally, the procyanidines in Revivogen have been shown in Japanese studies to be very potent stimulators of hairs into the growth phase, even more than Minoxidil.

Morphollica.com: Lately liposomal delivery is becoming quite popular. Do you plan on producing a liposome-based Revivogen product? I would personally be very enthusiastic about such a product. I know you are happy with your current delivery mechanism, but some people prefer not to use topicals containing alcohol.

Dr. Khadavi: Revivogen uses the Transmerol Follicular Delivery System to deliver the active ingredients into the hair follicle where hair loss actually occurs. The Transmerol Follicular Delivery System is a specific type of Liposomal Delivery. As you may know there are over 300 forms of Liposomal Delivery, and Revivogen uses a particular type to delivery the active ingredients into the hair follicle since each of the ingredients are unique and need special attention to allow the most effective delivery.

Morphollica.com: Last year you mentioned that you were performing a placebo-controlled study, university-based and completely independent. You mentioned that within 6 months you may have some results to report. What is the status of this study? And since it has been over a year since we last spoke, what results have you seen? Have you published the results yet, or are you planning to do so in the near future?

Dr. Khadavi: We have gotten a brief report from the study coordinator that the study is progressing well with the participants, but since the study is an open-enrollment with participants continuously enrolling as the study is progressing we do not have the any specific results. Once the final results have been obtained, submitted and accepted by a peer-reviewed medical journal, we will announce the results of the study.

Morphollica.com: I'm looking forward to the results. Tell us about Clearogen? Will it be useful for hair loss sufferers?

Dr. Khadavi: Clearogen is the first topical acne treatment that reduces the production of DHT (Di-Hydro-Testosterone) on the skin. DHT initiates the first phase of acne production since DHT stimulates overproduction of oil production by the sebaceous gland. This results in plugging of the follicle and growth of the bacteria called P. acne. This results in inflammation the ultimate acne lesion. Clearogen uses a topical cleanser, toner and lotion to reduce the production of DHT maximally, preventing the entire acne cascade.

Clearogen is used exclusively for acne patients and will not benefit the hair loss sufferers.

Morphollica.com: What do you foresee in the next two years with regards to progress in the treatment of androgenetic alopecia?

Dr. Khadavi: Since the last time we spoke I still believe that Follicular Neogenesis is still the most exciting development in hair loss in the last decade. Once all the process has been fully elucidated and then approved by the FDA, Follicular Neogenesis will make a dramatic difference in peoples lives.

Tricia · Post by **Tricia** » Mon Oct 17, 2005 5:18 am

I have a DHT / acne question. Did anyone notice a skin improvement with the intiation of propecia?

I hear all the time that there is a DHT / acne connection, but I never hear of a doctor prescribing propecia as an acne remedy.

Post by **HairLossFight.com** » Fri Oct 21, 2005 1:59 pm

Tricia,

I have always wondered the same thing. I suppose there has to be someone who can shed some light on this out there.

familyguy · Post by **familyguy** » Sun Oct 23, 2005 11:21 am

As someone who had pretty moderate acne in his teens, I tried several different treatments topical and then eventually pills. They pretty much already have several extremely effective ways to treat acne. With that said, I have noticed that propecia does a rather decent job at controlling acne (I have no noticable acne on my face now at least), but if I really did have an acne problem there are much better ways at treating it. The standard is usually a drug called Isotretinoin or more commonly Accutane. Actually I think since I took it in the late 90s they have come out with some newer drugs that are less harmful to your body and more effective. Not to mention I think they even have a laser therapy available for acne treatment too that looks pretty slick... I am not researched enough in acne treatments to know too much about it all though

Tricia · Post by **Tricia** » Mon Oct 24, 2005 8:15 am

I had the Smoothbeam laser treatment over a year ago. It was painful, but got rid of the acne on my chin. Many adult women get acne on the chin and it's hormone-related and difficult to treat. I was skeptical about the smoothbeam laser, but thought I'd give it a shot. It worked. I hardly ever get any acne on my chin and if I do, it's just tiny and goes away in a few days.

Jacob · Post by **Jacob** » Thu Nov 03, 2005 5:23 pm

I find it odd he'd say there's nothing new they could add that would make it better.

Post by **HairLossFight.com** » Sun Nov 06, 2005 9:23 pm

Jacob,

I can see why he would say that. I think it's a case of "if it ain't broke, don't fix it." The formula works for a lot of people according to them, so they probably feel it's good enough that it doesn't need changing unless adding something new can significantly improve their results.

That would be my guess anyway.

Jacob · Post by **Jacob** » Mon Nov 21, 2005 7:02 pm

There are plenty of things out there that are at least potentially more potent than what is in Revivogen. Some say apple peel extract is a step up from grape seed extract. As far as I know Revivogen uses gse which contains procyanidins..they don't use just the pro's extracted from the gse.

I see what you mean though about- if it ain't broke..don't fix it. But there are so many products out there- the companies could say that. I'd agree more with that statment if more were posting great results with Revivogen.

BTW..if I see anything added after 11/21/2005 that was discussed or known about prior to 11//21/2005..I'm going to have a field day

Post by **HairLossFight.com** » Wed Nov 30, 2005 12:09 am

I guess that would be understandable.

Jacob · Post by **Jacob** » Tue Feb 27, 2007 6:08 pm

And I guess it was broken...they just added 2 new "anti-dht" ingredients

Jacob · Post by **Jacob** » Thu Mar 01, 2007 4:18 pm

Ok..I'm going to go ahead and have a field day.

They added these ingredients(anti-dht ones) after saying this??

From researching and testing other ingredients that could potentially be used in Revivogen, we are currently not adding any new ingredients. This is due to the fact that maximal inhibition of DHT has been achieved with the active ingredients of Revivogen since the active ingredients that are being used in the current Revivogen formula are the most potent of all the ingredients available to us that are natural

Jacob · Post by **Jacob** » Tue Mar 13, 2007 6:03 pm

I asked him about this in the expert Q&A section...nothing yet. I see he has responded to some others since then..hopefully the date that's shown is the date he responds to them and not the date the question was asked

Post by **HairLossFight.com** » Tue Mar 13, 2007 8:43 pm

The date that's shown is the date he answers them.

Due to a problem with my mail server he wasn't receiving questions for a while so there is a backlog in his queue.

Jacob · Post by **Jacob** » Wed Mar 14, 2007 8:51 am

I also emailed him/Revivogen some time ago with the same question. Again..nothing........

Jacob · Post by **Jacob** » Thu Apr 12, 2007 10:12 am

No response either by email or the Q&A section here. I've never really cared much for the company..and this doesn't help. I'd really like to know how they get their foot in the door with all these hair loss websites, because there are plenty of other very good products out there..and imo, better ones.

Carry on

Post by **HairLossFight.com** » Mon Jul 23, 2007 9:39 pm

In the case of this website, I contacted them and asked if they would be interested in joining the Q&A.

Jacob · Post by **Jacob** » Tue Jul 24, 2007 1:37 pm

I thought they already were/did? I noticed at another related website the owner there still hasn't put up his interview with them(unless I missed it)..and it's been months since he sent the questions in.

Post by **HairLossFight.com** » Tue Jul 24, 2007 8:18 pm

Hey Jacob, long time no see. What I meant was that back when I originally was looking for people to join the Q&A I approached Dr. Khadavi and asked him to join.

Jacob · Post by **Jacob** » Wed Jul 25, 2007 2:08 pm

Ah..I see. I was having a Monday on a Tuesday

Post by **HairLossFight.com** » Wed Jul 25, 2007 4:14 pm

Anyway, it's been a while since any of the docs answered any of their questions. I'll be contacting them all to get them back into it. In addition, I think it's time to search for some new members of the panel as well.

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