Jacob, Pomegranate Peel

James · Post by **James** » Sun Mar 12, 2006 8:43 pm

Jacob you posted some info in Pomegranate peel in another forum. Do you know of any place to get this stuff? It seems really good for health in general, and maybe a little benefit on hair. Do you think that taking green tea extract and this stuff would be overkill?

Post by **HairLossFight.com** » Mon Mar 13, 2006 1:27 pm

From Pubmed:

Studies on antioxidant activity of pomegranate (Punica granatum) peel extract using in vivo models.

Chidambara Murthy KN, Jayaprakasha GK, Singh RP.

Government College of Pharmacy, Bangalore 560 027, India.

Pomegranate (Punica granatum) peel extracts have been shown to possess significant antioxidant activity in various in vitro models. Dried pomegranate peels were powdered and extracted with methanol for 4 h. The dried methanolic extract was fed to albino rats of the Wistar strain, followed by carbon tetrachloride (CCl4), and the levels of various enzymes, such as catalase, peroxidase, and superoxide dismutase (SOD), and lipid peroxidation were studied. Treatment of rats with a single dose of CCl4 at 2.0 g/kg of body weight decreases the levels of catalase, SOD, and peroxidase by 81, 49, and 89% respectively, whereas the lipid peroxidation value increased nearly 3-fold. Pretreatment of the rats with a methanolic extract of pomegranate peel at 50 mg/kg (in terms of catechin equivalents) followed by CCl4 treatment causes preservation of catalase, peroxidase, and SOD to values comparable with control values, wheres lipid peroxidation was brought back by 54% as compared to control. Histopathological studies of the liver were also carried out to determine the hepatoprotection effect exhibited by the pomegranate peel extract against the toxic effects of CCl4. Histopathological studies of the liver of different groups also support the protective effects exhibited by the MeOH extract of pomegranate peel by restoring the normal hepatic architecture.

Anti-oxidant activity ... good.

SOD decrease? Not sure how good that would be for hair loss given that SOD is supposed to help. Jacob? 5001matt?

Jacob · Post by **Jacob** » Wed Mar 15, 2006 5:14 pm

Sam..I had to reread that about 5 times before I got it

The CCI4 is carbon tetrachloride. Notice after that it says:

Pretreatment of the rats with a methanolic extract of pomegranate peel at 50 mg/kg (in terms of catechin equivalents) followed by CCl4 treatment causes preservation of catalase, peroxidase, and SOD to values comparable with control values

Don't you EVER do that to me again

James...I'm going to ask Beyond a Century if they plan on carrying it. So far I came across http://www.noveya.com/RawIngredients.htm (as a topical maybe?) and http://www.somaluna.com/product.asp?p=317

BTW..for those who haven't seen what I posted elsewhere: http://www.nutraingredients.com/news/ng ... ihstckkuay

Post by **HairLossFight.com** » Wed Mar 15, 2006 8:32 pm

Oops. Yeah, just read it again another couple of times before I caught it.

But still doesn't make sense to me. Who cares if the levels matched the controls after the pomegranate seed extract followed by CCI4 was applied?

I guess I'm not sure what purpose the CCI4 is serving in that study. It would have been better IMO if they said there was an INCREASE after the pomegranate extract if you ask me.

Anyway, as for pomegranate itself, I love that fruit. The fresh juice from that stuff is absolutely delicious. Maybe I'll have more of it now.

Sam

Jacob · Post by **Jacob** » Sun Mar 19, 2006 8:05 pm

I think it's like the liposomal SOD and UV protection:

Decreased skin superoxide dismutase activity by a single exposure of ultraviolet radiation is reduced by liposomal superoxide dismutase pretreatment.

Miyachi Y, Imamura S, Niwa Y.

The effect of a single exposure to UV radiation on skin superoxide dismutase (SOD) activity was examined in mice. A significant decrease in SOD activity was observed 24 and 48 h after UV irradiation, returning to the normal level by 72 h after irradiation. Decreased SOD activity after UV exposure was reduced by pretreatment with liposomal SOD (L-SOD). This protective effect of L-SOD may have potential clinical application for photodermatologic reactions.

I guess they're saying there's protection from "SOD degradation" in both cases.