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Topical application test
The hair of the lumbar region (small 5cm patch) of six C3H mice was cut and 0.1ml of SOD extract was applied twice a day, until hair growth was observed. The area of hair growth was monitored with an image analysing apparatus on days 14, 21 and 28 following the start of the test.
At 1% concentration of SOD, hair growth response was observed in all cases after 14 days and hair growth rate was observed in all areas of treatment. At 0.5% concentration, hair growth response was observed in all cases and hair growth rate was 90%.
In comparison, Minoxidil (2% Rogaine, Upjohn) showed hair growth response for 5 out of the 6 animals in 28 days and hair growth rate was at 57%
In Vitro test
It has been shown that Minoxidil increases the DNA synthesis of skin hair follicle and the synthesis of keratin in the hair follicle (Buhl AE et al., J Invest Dermatol 1991 May; 96(5):73S-74S) so it was decided to use the same test for Superoxide Dismutase for a fair comparison. Addition of only 5-10 microM of SOD extract provoked hair follicle protein synthesis which was 100-200% higher than that of Minoxidil (2%)
We are aware that Minoxidil is usually used at 5% concentration or higher. Nanogaine is formulated with 2% SOD in addition to it's other actives such as Lo-Seb TM and Capilecti"
http://www.nanogen.co.uk/nanogaine.htm