For those going the internal "dht inhibiting" route..
"Triarco Industries, Inc. announces very encouraging results of a pilot clinical trial for their patented product Alphastat, which inhibits 5-alpha reductase. The three-month study on male patients ages 55-68 reported a 17% decrease in Prostate Specific Antigen (PSA), and a 40% decrease in dehydrotestosterone (DHT), indicating a rise in total testosterone in these subjects.
Urogenital symptoms including increased urgency to urinate, reduced urinary stream and nocturia decreased in 80% of the patients. There were two reports of increased sexual function with one report of an increase in spontaneous erections after not having experienced erections approximately 15 years.
Negative side effects of pharmaceutical treatments for elevated PSA and DHT may include hypotension, sexual dysfunction and reduced libido. There were no reports of any negative side effects in this study and no reports of any compliance issues.
We are very pleased with the results of this clinical study because it confirms the results of the pre-clinical studies and is, to our knowledge, the first natural product shown to lower PSA and DHT levels in humans."
http://www.triarco.com/pressreleases.ht ... th,%202004
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In Vitro Study:
A Preliminary investigation of the Enzymatic Inhibition of 5α-reductase and Growth of Prostatic Carcinoma Cell Line LNCap-FGC by natural Astaxanthin and Saw Palmetto Lipid Extract in vitro.
ABSTRACT
Inhibition of 5α reductase has been reported to decrease the symptoms of benign prostate hyperplasia (BPH) and possibly inhibit or help treat prostate cancer. Saw Palmetto berry lipid extract (SPLE) is reported to inhibit 5a-reductase and decrease the clinical symptoms of BPH. Epidemiologic studies report that carotenoids such as lycopene may inhibit prostate cancer. In this investigation the effect of the carotenoid astaxanthin, and SPLE were examined for their effect on 5α reductase inhibition as well as the growth of prostatic carcinoma cells in vitro. These studies support patent #6,277,417 B1.
The results show astaxanthin demonstrated 98% inhibition of 5a-reductase at 300 mg/mL in vitro. Alphastat, the combination of astaxanthin and SPLE, showed a 20% greater inhibition of 5a-reductase than SPLE alone in vitro. A nine day treatment of prostatic carcinoma cells with astaxanthin in vitro produced a 24% decrease in growth at 0.1 mcg/mL and a 38% decrease at 0.01 mcg/mL. SPLE showed a 34% decrease at 0.1 mcg/mL.
Conclusions: Low levels of carotenoid astaxanthin inhibit 5α reductase and decrease the growth of human prostatic cancer cells in vitro. Astaxanthin added to SPLE shows greater inhibition of 5α reductase than SPLE alone in vitro.
http://www.triarco.com/alphastat.htm
Also..click on "Alphastat clinical study" in that last link.
Astaxanthin topically? I'm sure it'd be colorful..........
Alphastat- SP/Astaxanthin
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