Hair loss: The true cause(s)

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backwardsbalding
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Posts: 1
Joined: Wed Jul 03, 2013 2:46 pm
Hair Loss Type: Androgenetic Alopecia (Male Pattern Baldness)
Norwood Level: Norwood II
Have you had a hair transplant?: No
Treatment Regimen: ERT

Hair loss: The true cause(s)

Post by backwardsbalding » Wed Jul 03, 2013 3:05 pm

Male Pattern Baldness: Why you really are losing your hair

Hair growth or hair loss is effected by multiple factors much like the growth of a plant in your garden. You do not simply plant a seed in dry ground and expect the sun to do all the work you of course need water. Additionally this water needs certain nutrients to maintain the optimal level of plant health. Well much like a plant needing sun, water, and nutrients, hair needs nutrient rich blood, sun and hormones. While some hormones promote body and facial hair others promote hair on the head. It just so happens that the hormone that promotes facial and body hair in men also damages hair on the head under a "wrong" condition. I will get to that wrong condition in a moment. First, what is this hormone that promotes facial and body hair and is also the sole cause for Male Pattern Baldness (MPB)? It's called Dihydrotestosterone (DHT) and it's a potent androgen hormone that is converted from Testosterone (T) in many places but primarily in your Prostate. This is in no way my opinion it is common knowledge that DHT is the culprit behind MPB and current medications on the market aim to stop this conversion of T to DHT. The only medication that has had any real success with this was first introduced to the public under the brand name Propecia. Propecia claims to block the enzyme responsible for making this conversion of T to DHT and that enzyme is called the 5-Alpha Reductase. If you don't already know, an enzyme is a catalyst that speeds up or in some cases makes a chemical reaction happen that otherwise would not have been possible. Propecia makers originally prescribed the medication for people experiencing Benign Prostatic Hyperplasia (BPH). In other words BPH is simply an enlarged prostate usually noticed by an increased in urine frequency and in most cases difficulty urinating. Propecia works by reducing the size of the prostate and it was soon after discovered to grow hair on balding crowns of men. Sense then it has been hypothesized that Propecia blocks the T to DHT conversion via the inhibiting of the 5-Alpha Reductase. Its mechanism for doing this or to what degree it does is irrelevant because the reducing of the prostate is the key to re-growing hair. As Testosterone leaves the testicle(s) along with Sperm it travels to the Prostate where the semen is excreted through Dermal Cells to join the sperm to make the total ejaculate. Semen from the prostate keeps the sperm alive in the highly acidic Vagina. 95% of the Testosterone that gets to the prostate is converted into Dihydrotestosterone. These hormones are very much essential for reproduction and go on to be key in mammalian hair growth. At age 12 your prostate is only the size of pea where it begins a rapid growth phase that will slow down in your early 20's. After you have reached this age and subsequently this size prostate you now are able per ejaculation to put out more DHT than ever before. Regularly high DHT levels will not be a problem as with all sex hormones excess amounts will expelled out of your body VIA acne. Now this would be fine if it were not for that "wrong" condition that I mentioned in the beginning of this article. Hair loss has a cofactor much like sun and water both are required for plant growth; similarly two factors are required for hair loss to occur. Cofactors are very common in all biological processes and disruptions. The cofactor of DHT causing hair loss is a tight scalp that restricts blood flow. Male and female scalps can become very tight for a number of reasons. It is in this tight scalp that DHT cannot make it across the tiny capillaries running across the top of your head. The DHT literally gets clogged in the "run off" capillaries to the hair follicle and the hair starves to death. The tightness of the scalp comes in many forms and where that pressure is applied is what will begin this balding process subsequently determining the pattern at which someone will lose hair. Also, how fast the pressure is applied will determine how quickly you lose your hair in those areas. For some people the pressure gives at certain areas so they don't lose as much hair other its all over and for some they have such thick loose scalps DHT never has a chance to cause hair loss. The list of possibilities in modernized societies contributing to a tight scalp and lack of blood flow is endless. The major players include stress, awkward sleeping habits and positions, sedentary lifestyles, excessive squinting, injuries and disease, lack of good fat in the die, too much processed Carbohydrates in the diet, and of course medications. Stress is by far the worst because it increases muscle tension in the shoulders and neck subsequently pulling on the 3 major muscles of the head. These muscles in the head are; Frontalis, Temporal and Occipitals http://medical-transcriptionist-referen ... scles.html. If you view the link here you will be able to see why these areas are prone to tightness due to stress and how they connect to the muscles of the shoulders and neck. The next noteworthy observation one might make is the absence of muscles on the top of the head where coincidentally the worst cases of hair loss experience an entirely bald head. A very useful way of measuring a bald head is picture diagram called the Norwood Scale and the worst is a Norwood 7 .http://www.greathairtransplants.com/ima ... wood12.jpg. This area that covers the top of the head is for most your life a generally loose, thick and tough layer of skin called the Galea Aponeurotica http://en.wikipedia.org/wiki/Galea_aponeurotica. The Galea for short, is attached to the muscles of the head and is victim of the downward pulling of these tight muscles. Due to the shape of the skull as it grows into adult hood the downward pressure begins in certain places and has certain pressure giveaways, rather the pressure is stronger and weaker in different places on the head. This allows for various balding patterns but almost all having similarities. This is really where genetics come into play and as soon as you finish reading and go about your life you will quickly start noticing this next observation. Children who acquire genes that encourage protruding eyebrows with inward and relatively small foreheads will be at a huge advantage against hair loss because the lack of pressure points. People who inherit relatively larger protruding foreheads with little to no protruding of the eyebrows unfortunately are at in increased risk of balding because of the pressure points created. The best way to understand this is by simply observing someone who has severe hair loss and comparing their forehead and brow shape to someone you know with no hair loss at all. An excellent explanation of this diagram from a mathematical perspective is found here. http://www.worldhairloss.org/index.php/ ... _baldness/. Unfortunately medical researchers and doctors pinpoint a gene that predisposes you to just about anything and focus primarily on genetics which is why after 100 years of research they have found no reasonable treatment option. They over simplify Genetics which is why genetic hair loss as they say, can come from your mother, father, or distant relative. Genetics is always the scape goat in medicine when they can’t explain something. The fact is genetic hair loss should be restated as increased predisposition to Male Pattern Baldness caused by inherited genetic skull shape, muscle configuration even inherited habits. Many learned behaviors get confused with genetics such as diet, medications, or sedentary lifestyles which all can have mild affects on accelerating hair loss in someone predisposed to it. For example, Motrin is a strong Vasoconstrictor that if taken regularly will contribute to someone already having hair loss. Studies show parents who rely on Motrin for pain relief often have children who do the same this could be seen as genetic although it’s merely an inherited behavior. Food contributes to hair loss because high processed foods cause plaque induced high blood pressure which will slow down free blood flow while fruit and vegetables counteract these substances. Diet change alone will not stop hair loss but if all other factors are corrected diet too must be addressed for optimal growth. The simple explanation is a tight scalp renders your head in a condition able to cause hair loss by slowing blood flow once this happens the little things like bad food and medication can also contribute but will not do so if your scalp remains loose and thick. The simple fact is ejaculating often will not cause hair loss if you do not have a tight scalp and if you do have a tight scalp ejaculating excessively will accelerate the condition. Citations clearly support this statement and are listed below. The patterns of hair loss men experience and the fact that it is localized to not only the head but predominantly the Galea clearly proves the "Genetic individual sensitivity" theory is completely bogus. Genetic Variation would not allow such broad sensitivity to skip the back and sides of the head let alone the rest of the body while seemingly following a very noticeable pattern in almost all Male Pattern hair loss sufferers. The engineers I have discussed this topic with clearly understand it unfortunately we have handed hair loss research to doctors who are way to hung up on genetics and this crazy belief that every hair follicle has its own sensitivity genetically programmed. Just for some unexplained reason most people experience it in a pattern 99% the time only on the top of their head where the Galea exists.


This study shows one ejaculation a week will rise DHT levels and its the only hormone effected by ejaculation.
http://www.bmj.com/content/310/6990/1289.full

As Testosterone leaves the testicle(s) along with Sperm it travels to the Prostate where the semen is excreted through Dermal Cells to join the Semen to make the total ejaculate. Semen from the prostate keeps the sperm alive in the highly acidic Vagina. 95% of the Testosterone that gets to the prostate is converted into Dihydrotestosterone.
http://www.ncbi.nlm.nih.gov/pubmed/2055645.

Botox study Shows the importance of circulation and a cushioned scalp
http://journals.lww.com/plasreconsurg/F ... um.79.aspx
Minoxodil, one of the 2 medications that works is simply a vasodilator that increases blood flow. We have many vasodilator medications none of which work localized like minoxidil does.
http://www.ncbi.nlm.nih.gov/pubmed/6239893
This study shows the significant decrease in blood flow to the balding areas where as people not balding had no decrease in blood flow at all. I personally confirmed this research with the doctor and he was astonished that the common belief is hair loss has nothing to do with blood flow.
http://www.ncbi.nlm.nih.gov/pubmed/8628793

study showing a rise in testosterone after day 7 of abstinence suggesting at the very least a week is how long it takes for your body to balance its hormones out following ejaculation
http://www.ncbi.nlm.nih.gov/pubmed/12506329

History of Propecia:

In 1974, Julianne Imperato-McGinley of Cornell Medical College in New York attended a conference on birth defects. She reported on a group of hermaphroditic children in the Caribbean who appeared sexually ambiguous at birth, and were initially raised as girls, but then grew external male genitalia and other masculine characteristic post-onset of puberty. Her research group found that these children shared a genetic mutation, causing deficiency of the 5α-reductase enzyme and male hormone dihydrotestosterone (DHT), which was found to have been the etiology behind abnormalities in male sexual development. Upon maturation, these individuals were observed to have smaller prostates which were underdeveloped, and were also observed to lack incidence of male pattern baldness.[47][48]

In 1975, copies of Imperato-McGinley's presentation were seen by P. Roy Vagelos, who was then serving as Merck's basic-research chief. He was intrigued by the notion that decreased levels of DHT led to the development of smaller prostates. Dr. Vagelos then sought to create a drug which could mimic the condition found in the pseudo-hermaphroditic children in order to treat older men who were suffering from benign prostatic hyperplasia.[49]

In 1992, finasteride (5 mg) was approved by the U.S. Food and Drug Administration (FDA) for treatment of benign prostatic hyperplasia (BPH), which Merck marketed under the brand name Proscar.

In 1997, Merck was successful in obtaining FDA approval for a second indication of finasteride (1 mg) for treatment of male pattern baldness (MPB), which was marketed under the brand name Propecia.
http://en.wikipedia.org/wiki/FinasterideA few key points about castration and hair loss. :
Without male androgens in the testicles to pass to the prostate via ejaculation or at low levels in regular maintenance the prostate will shrink and nearly disappear. Castration has been proven to completely stop hair loss if castrated after hair loss has started. Castration also has shown to completely avoid hair loss in those who are castrated prior to puberty.
http://jcem.endojournals.org/content/84/12/4324.long

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