@israelite
I noticed you are going to use adenosine, correct?
I don´t have the time to elaborate much on it, so just a few words.
Google for adenosine and fibrosis ...
http://www.ncbi.nlm.nih.gov/pubmed/19949965
http://www.ncbi.nlm.nih.gov/pubmed/19639289
http://www.ncbi.nlm.nih.gov/pubmed/19858092
Which experiments on Adenosine are published?
http://www.nature.com/jid/journal/v127/ ... 0728a.html
http://www.ncbi.nlm.nih.gov/pubmed/11886528
http://www.ncbi.nlm.nih.gov/pubmed/17301835
http://www.ncbi.nlm.nih.gov/pubmed/19239555
http://www.ehrs.org/conferenceabstracts ... tanabe.htm
Experiments in vitro with DP cells don´t tell you anything about fibrosis, there are no fibroblasts present that will be turned into myofibroblasts during fibrosis.
There is a study in women which lead to a little bit thicker hair shafts. Pretty weak if one recalls that there is a publication which states that Minoxidil works by Adenosine, but that is another issue; not every publication is 100% right.
But women likely don´t have that much of a problem with fibrosis like hardcore androgenetic alopecia male may develop it.
ALSO, fibrosis does not develop over night, it takes some time. Therefore long term studies are needed in case of Adenosine I suggest. We don´t have them. The study in men took 6 months. That is not short, but is it long enough?
There is a study also in men. But it is mentioned only on a poster on a hair conference if I recall that right. I searched for the publication of this data in a journal but I couldn´t find it. So why haven´t they published their data in men in a journal ?? Why did they publish only their data from the study in women? Well, maybe I was just not able to find that publication, but if there is none there is something fishy.
I do thoroughly screening of substances before I incorporate them and Adenosine has not qualified yet.
The point is:
Why risk fibrosis in the long term? It is not sure that fibrosis will develop but why risk it? For a little bit thicker hair shaft diameter? You can also swallow choline stabilized Silicilic acid for that purpose.
However, Adenosine still may be worth using it, I just wanted to point out the expected benefits, the danger, and the current data. I guess my text is missing some points and links and it is also not well written but it is late at night now in Germany and I am tired
If you still want to mix it yourself, don´t overdo it, stick to their concentration and vehicle. There is likely a reason why they use only 0.75% and not more. They may have done more experiments than they published.
One last point: Every person and every skin is different. The authors mention "asian women" in the headline of their publication. Fibrosis depends on many factors in the skin and some people are more prone to it than others. I don´t know if asians are more or less prone to it but I know there are difference between individuals.
The problem with Adenosine is:
It plays a certain role during wound repair. Its anti-inflammatory action "says": "Stop inflammation now, it is time to heal the wound." But what is needed in order to heal a wound? You need new vascularisation, so adenosine increases VEGF, which is good for hair growth. Unfortunately adenosine also increases profibrotic mediators that included TGF-β1, IL-1β, IL-13, plasminogen activator inhibitor-1 (PAI-1), and osteopontin. Since TGF-beta has anti-inflammatory properties the anti-inflammatory action of adenosine is likely at least in part mediated by TGF-beta. Adenosine increases collagen production in order to close the wound. Since it is vital for a living creature to close a wound quickly, fibrotic scars are less of an issue for the body, but closing the wound fast is important.
Because of this double action of Adenosine, it is difficult to use for hair growth. If there is a beneficial concentration at all that works also long term, then you better stick to that concentration and don´t mess with higher concentrations. Two opposing mechanisms usually lead to an optimal dosage, a dome-like shaped effect with a maximum but for high concentrations the effect can also become negative. Some substances have even a biphasic behavior, they have only a beneficial concentration window, means for lower concentration the effect is also not only low but negative. If I recall that right Caffeine shows such an biphasic effect on hair growth, which is not surprising since it is an adenosine receptor antagonist. Why is Caffeine working at all? Sorry, I don´t have the time to elaborate on that. I just want to say, Adenosine and Caffeine are difficult to use, the right concentration is hard to hit and since every person is different, every skin status different I find it risky. Also keep in mind that people use different amounts and use it with a different frequency. So you have to make sure that you don´t use it more often than in the study and don´t use more milliliters per the same area as they did in the study. The study for men that is ... But do you have that study? That EHRS poster is not very informative when it comes to the above mentioned points, is it?
http://www.ehrs.org/conferenceabstracts ... tanabe.htm
Many question marks. If you use a substance with easy to handle window of action (broad and not biphasic) you cannot do much wrong but I don´t know if that is the case for Adenosine. It would not be my first choice for self-mixing. Recall the benefits:
"Treatment with either lotion resulted in a significantly decreased ratio of vellus- like hair and also significantly increased the ratio of thick hair, but did not change hair density."
No change in hair density.
Now make your choice.
Enough said, I wish you luck with whatever you do.
: http://www.functional-products.net/en/p ... chreibung/
...how are you able sell it at quite a reasonable price..especially with some of the ingredients and the encapsulation tech? I'm assuming quantity and using Amazon helps a bit. 
and is it something you'd put in the topical as well? 