Stevia

[jedi2001]

Tell us more about the stevia herbal extract effect for unblocking DHT receptors of the hair follicle. Upregulation of receptors can be a problem with prolonged hair follicle exposure to DHT. Stevia might help there.

[Guest]

What do you mean? Makes no sense to me.

[Jacob]

He's probably referring to things such as this:

3 - Hormonal activity
Uehara et al (1982) examined the affinity of the stevioside by androgenic receptors directly in homogenization of cells of the submandibular salivating glands of male mice and normal puberty females and of prostate of normal puberty mice. Quotas of the overskimming of centrifugation of the homogenates were incubated with (H3) 5 -a- di-hidrotestoreron in the absence and in the presence of concentration 100 times greater than 5a-DHT radio inert or stevioside, for the evaluation of the connecting activity. Evaluating further the effects of aqueous extract of Stevia in the endocrinous sphere, the same authors ( Silva Filho et al, 1986), demonstrated that the chronic administration (60 days) of these extracts to rats, since the pre-puberty age, did not produce significant alteration on the following parameters: glycemia, sericeous levels of tri-idotironin, tyrosine and T3 reversa; content of zinc in the prostate, testicles, submandibular salivating glands and pancreas; hydric content in the testicles and prostate; curve of gain of bodily weight; terminal weights of testicles, prostate, submandibular and adrenal glands, union of [3H]- methyltrienolon ( a synthetic androgen) to the cytostatic fraction of the prostate. It was observed only a reduction of about 60% in the weight of the seminal vesicle, both in absolute terms and in relation to the corporal weight. The authors observed also that the stevioside showed a small activity of displacing the DHT previously connected to its receptors in the prostate. No activity related to the stevioside was observed in relation to the receptors of the salivating glands of male and female rats. They concluded that there were no possibilities , relying just on the data obtained, to confirm that the stevioside has any anti-androgenic activity.

Still with hormonal connotation, Dorfman and Nes ( 1960), studied the activity anti-androgenic of steviol and di-idrosteviol, di-terpenic acids not steroidals derived from the sweet glycosides of the Stevia. The reader is reminded that these two substances are not found free in the Stevia rebaudiana.

The anti-androgenic action was measured using the method of monitoring the growth of the crest of two days old male chicks, stimulated by testosterone. The drugs were injected daily during 7 days. At the end of the treatment the crests of the chicks were removed and weighed. Both the steviol and the di-idrosteviol showed significant results when the doses applied to each chick reached 3.0 mg. Studying these results , even assuming that all stevioside were hydrolyzed to steviol in the gastrointestinal tract, after the ingestion ( Wingar et al, 1980), this level would be reached only if the amount ingested, all at once, equaled 1.26 g/kg of body weight in an adult individual, representing 180 times its maximum daily necessity in terms of sweetening needs.

Dorfman and Nes ( 1960) tested also the di-idrosteviol on the activity anti-androgenic in castrated rats. The results showed that this molecule does not produce any effect on the seminal vesicle, prostate and supporting anal muscles and also it was not effective to inhibit the action of the testosterone in rats, even in doses of 5 to 20 mg per animal of average weight of 90 g.