Kevis the World's Most Expensive Shampoo Cures Baldness

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Jacob
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Kevis the World's Most Expensive Shampoo Cures Baldness

Post by Jacob » Wed Oct 14, 2009 7:56 am

Saw this at another site. And of course I believe it's the cure :-s
(I can't imagine that's Kevis' own headline..weren't they in trouble with the FDA before? Maybe I'm thinking of another company..nothing is coming up in a search)

http://www.pr.com/press-release/178576
Kevis discovered a complex molecule in the human umbilical cord and semen that will keep your follicle free of DHT. Kevis now has this molecule bio-engineered at a cost of $60,000.00 per kilo. Kevis has just released KEVIS 8: "Our eighth generation product also contains our new exclusive enzyme, Tricozyme which dissolves DHT as an additional weapon on our attack on hair loss." Adds Reichenberg. "Once follicles stop growing they stay dormant, but alive, for as much as eight years and can be revived with Kevis."
http://www.youtube.com/watch?v=gWTABPhBE6g

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Re: Kevis the World's Most Expensive Shampoo Cures Baldness

Post by Jacob » Wed Oct 14, 2009 8:03 am

And if anyone cares to figure out how to embed Youtube vids in here..knock yourself out: http://www.phpbb.com/community/viewtopi ... 4&t=546007

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Re: Kevis the World's Most Expensive Shampoo Cures Baldness

Post by Jacob » Wed Oct 14, 2009 8:10 am

The "HUCP" sounds familiar. Either was mentioned before prior to the product coming out or it's been in one of their other products...or this isn't as new as the PR made it sound...or :-s

http://www.kevis.com/products/kevis_8.aspx

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Re: Kevis the World's Most Expensive Shampoo Cures Baldness

Post by Jacob » Wed Oct 14, 2009 8:19 am

The company behind it all: http://www.farmaka.it/

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Re: Kevis the World's Most Expensive Shampoo Cures Baldness

Post by OverMachoGrande » Wed Oct 14, 2009 8:28 am

You have to have admin powers, and install a "mod". It's really easy to do, but what I do to get around it that's almost as good is just post a screenshot of the video.

I'm sorry that what I'm going to say sounds rude, but man... Kevis freaking LOVES semen. They can't stay away from it. I just don't even want to think about the chinese "work shops" they use to get it, either.

I'll say this about Kevis, though... I used it back in the mid/late 90's -when I think it was made up of bird embryos or something- and it was FANTASTIC at providing a cosmetic benefit to my hair. I only had the money to use it for six months, but it really was an instant change. Don't know if it did one single thing for hair loss, but it made my hair look so much better that people almost instantly were complementing it.

If I was rich and had money to just throw away -and if that original product was still available- I'd maybe get some to try it again just to see if it accented my laser hair.

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Re: Kevis the World's Most Expensive Shampoo Cures Baldness

Post by hapyman » Wed Oct 14, 2009 10:17 am

The active molecule that supposedly blocks DHT at the receptor sites is called HUCP or (H.U.C.P.)

Found this:
European and American Testing on Kevis Products
Kevis Hair Lotion

1. Double-blind placebo-controlled study with Kevis Lotion

In this experiment, which allows a casual interpretation for comparable groups, the effectiveness of Kevis in comparison with a placebo is revealed in a statistically significant manner:

1. On the percentage of telogen hairs: in 90 days it decreases by 16% in the Kevis group, and only by 6% in the placebo group;

2. On the number of hairs counted in the three comb-stroke test: (a) in the Kevis group it decreases by 56% in 60 days and by 59% in 90 days; (b) in the placebo group it only decreases by 18% in 60 days and by 16% in 90 days.

3. On the number of hairs pulled out in the traction test: (a) in the Kevis group it decreases by 29% in 60 days and by 47% in 90 days; (b) in the placebo group it only decreases by 5% in 60 days and by 7% in 90 days.

Hotel-Dieu, Marseille, France. Director: Y. Privat.
2. Les Nouvelles Dermatologiques 18-19 May. 1990 (Marseille, France).

Localization of 5-alpha-dihydr-testosterone in the hair follicle: employment of monoclonal antibodies in the evaluation of the anti androgenetic activity of H.U.C.P.

RESULTS: Investigation of the sections which had not been subjected to any treatment at all revealed the presence of high positivity for 5-alpha-DHT in the external follicle sheath and no apparent similar positivity in the cellular matrix. However, in the telogen follicles of a series of sections, there was evidence of a certain amount of cytoplasmatic positivity for 5-alpha-DHT also in the matrix, always associated with the presence of 5-alpha-DHT in the follicle sheath. Furthermore, a modest diffusion of the chromogen in between the cellular spaces was also noted and must be considered during interpretation of the prepared sections. Observation of the sections obtained from the biopsies taken in the skin areas subjected to the action H.U.C.P. revealed an almost total absence of 5-alpha-DHT, both in the external sheath and the follicular matrix. These findings were evident in all the subjects involved in the investigation.

University of Pavia, School of Dermatology, Milan, ltaly E. Berardesca, L. Miori, G. Rabbiosi, R. Venafra.
3. Report of a treatment with topical solution of the product named "Kevis" used for subjects suffering from defluvium and/or alopecia

CONCLUSIONS: After use for 60-90 days, the topical product applied in 43 male and female subjects suffering from slight or moderate degree alopecia has exerted an action which may be globally defined as favorable. This positive evaluation is justified by the microscope finding that has evidenced a significant increase of hair in active growth phase (anagen phase) after application of the topical product.

The clinical evaluation has been expressed by the dermatologist about the effect of the treatment, globally considered: this resulted to be very favorably in 26% of the cases versus 21% of the cases, where it was not possible to observe any effect. In addition, in the remaining 59% of the cases a positive effect has been found, however modest its entity had appeared.

A more favorable evaluation of the topical drug was expressed by patients about "acceptance" of the product: very good for 41% of the patients, with one unsatisfied patient only. Same favorable evaluation expressed by patients about efficacy: very good or good for 60% of the patients, while an unfavorable opinion was voiced by 3 patients (7%).

As to pruritus, the preparation has shown to be effective against this symptom, with statistically significant result, but three cases where drawbacks were present (onset or increase). On the other hand, the preparation has shown to be poorly suitable for the treatment of pityriasis scaling: patients who obtained improvement are counterbalanced by patients where a limited enhancement of scaling had appeared, so that the comparison did not result as statistically significant.

After performance of traction test, the number of subjects was halved who presented an intense or very intense defluvium, with a markedly significant improvement after treatment. At last, the drawbacks connected to use of the topical product have appeared to be limited: in 9% cases, increase of pityriasis scaling, and in 7% cases, onset or increase of pruritus.

University of Pavia, Dermatology Clinic July 1, 1985. Director: Professor G. Rabbiosi
4. La Medicina Estetica numero 4, 1986 (Editrice Salus Internazionale-Roma). Action of a topical product on the scalp.

43 patients affected by telogen effluvium were subjected to treatment with a preparation for topical use, containing a mixture of natural mucopolysaccharides and a vasodilator. The parameters evaluated were resistance to traction and trichogramme; evolution of seborrhea, pruritus and dandruff; trialist global objective judgment; patient's global subjective judgment and his/her acceptance of the treatment. From the statistical elaboration of the data obtained, it can be concluded that the topical product exerts a favorable action on defluvium and seborrhea; while the response to pruritus is less evident and to pityriasis is irrelevant.

University of Pavia, Dermatology Clinic. Director: G. Rabbiosi
5. La Medicina Estetica number 3, 1988 (Editrice Salus Internazionale-Roma). Double blind trial against placebo in the treatment of postpartum telogen effluvium.

A total of 50 women, aged between 20 and 35 years, mainly primiparae, affected by postpartum telogen effluvium, were divided into two randomized groups of 25 and treated, in double blind conditions, for a period of 36 days with a topical product indicated in the prevention of hair loss, compared with a placebo. The results, analyzed by the trichogram method and traction test, demonstrated the product's efficacy in favoring the return to the physiological state, while the excellent tolerability confirmed its safety.

Maggiore Hospital of Lodi, Italy. Professor Mario Goisis
6. Evaluation of Kevis Thinning Hair Product-RB B67 122

A twelve-week study was conducted using males and females to determine subjects' perceptions regarding the performance and acceptability of a topical hair preparation designed for persons with thinning hair. The product was generally perceived to provide a significant increase in hair body and fullness. A significant number of subjects also rated the product as beneficial in improving hair texture and decreasing fallout rate.

Study Date: July 5, 1988-November 22, 1988. Study Site: Hilltop Research, Miamiville, OH; Hilltop Research, Scottsdale, AZ.
7. La Medicina Estetica number 1, 1988 (Editrice Salus Internazionale-Roma). Report on the treatment with a topical preparation, Kevis, of volunteers affected by neoplasia and subjected to cycles of chemotherapy with cytostatic drugs.

In a clinical study performed in 61 patients subjected to chemotherapy with antiblastics (adriamycin and cis-platinum), a group of 32 patients received topical treatment with a new anti-alopecic preparation (KEVIS), while 29 patients who did not receive topical treatment were used as the control group. Based on the resultant objective observations (photographs, traction test), it was statistically demonstrated that Kevis is active, first, in slowing down drastic hair loss caused by antiblastic therapy, and second, in aiding the conditions of the scalp to return to the normal physiological state at the end of the chemotherapy cycle.

"S. Anna" Province General Hospital, Como, Italy. Director: Dr. Cosimo Epifani
Farmaka S.r.l. - Via Vetreria 1 - 22070 Grandate (CO)
Benveniste M.J. (1)
Di Vincenzo R. (2)
Gimenez Camarasa J.M. (3)
Fenton D. (4)
Peyri Rey J. (5)
Reunala T. (6)
Soragni A. (7)
Venafra R. (8)
Poma A. (9)

Local Treatment of Androgenetic Alpecia with Kevis. An international post-marketing survey on the results of clinical trials in patients treated for up to one year.
(1) Benveniste M.J., Dermatologist, Hotel Dieu, University of Marseille, France.
(2) Di Vincenzo R., Dermatologist, Varese
(3) Gimenez Camarasa J.M., Dermatologist, Hospital Del Mar, University of Barcellona, Spain
(4) Fenton D., Senior Registrar, St. Thomas' Hospital, London, U.K.
(5) Peyri Rey J., Head of Dermatology, Residencia Sanitaria de la Seguridad -- Principes de Espana, Barcellona, Spain
(6) Reunala T., Dept. of Clinical Sciences, University of Tampere, Finland
(7) Soragni A., Dermatologist, Varese, Italy
(8) Venafra R., R. & D. Director, Farmaka Research Centre
(9) Poma A., Clinical Research Associate, Milan, Italy
Foreword

In the treatment of androgenetic alopecia, systemic drugs with hormonal and/or vasodilating activity are generally devoid of any relevant therapeutical effect, other than those which are temporary or of scarce value, and represent a certain risk in terms of side effects. On the contrary, a lotion for topical use, Kevis, has been reported in literature as a very safe and reliable product for such an indication (1, 2, 3, 4, 5).

The two main active ingredients contained in Kevis are: 1. H.U.C.P., a biological complex with a high content of high molecular weight hyaluronic acid and proteoglycans; 2. Thioglycoran, i.e. glycosamine-glycan sulphates (GAGS). Thurfyl nicotinate (a well-known cutaneous vasodilator), Biotin, and Na-pantothenate are also contained in the formulation.

In a human pharmacology study, H.U.C.P. demonstrated its action in correcting the abnormal response of the sebaceous glands and hair follicles to the local effect of 5-alfa-dihydrotestosterone (5-alfa-DHT), which is considered as the major genetically programmed factor of the androgenetic alopecia process (Berardesca et al. 1990). Furthermore, H.U.C.P. has demonstrated its efficacy in prolonging the anagen phase of the hairgrowth cycle which is normally shortened during the androgenetic alopecia process (9, 10).
Conclusions

According to the cyclical schedule of treatment adopted (1 vial/day for 4 weeks; 1 vial every other day for 7 weeks; 1 vial/week for 28 weeks), Kevis is effective in producing a relevant improvement in the androgenetic alopecia process as early as in the first 3-4 months, demonstrated by the significant reduction in the traction test values, and confirmed by the judgement expressed both by the dermatologists and by the patients. At the same time, Kevis produces appreciable "aesthetic" effects, reported by the patients as an amelioration of appearance, manageability, and texture of the hair, and a general improvement in the look of fullness.

Apart from the very high rate of positive results in terms of general improvement, the interruption of the alopecic process, during treatment with Kevis for periods of up to one year, was apparent in practically the totality of the cases studied, thus representing a fact which is to be considered as one of the major and most important advantages offered by the use of this product.

Although the effects of treatment generally appear fairly soon, it must be noted that the best results are obtained progressively. It is, therefore, advisable to continue treatment for the recommended period, even if there is a delay in obtaining evident results.

It is likely that the prompt and stable improvement in the results of both the traction test and overall condition (reported by the doctors), as well as the prompt and stable interruption of hair loss (reported by the patient), are related above all to the efficacy of H.U.C.P. and Thioglycoran (GAGS) in correcting the abnormal response of the sebaceous glands and hair follicles to the local action of 5-alpha-DHT.

In this regard, it is also important to point out that H.U.C.P. and Thioglycoran exert a benefic action in deep cutaneous hydration (14) and in prolonging the anagen phase of the human phase of the human hair growth cycle, which is shortened during the evolution of androgenetic alopecia (10).

Improvement of appearance, texture, manageability, and look of fullness of the hair is expectable as a consequence of the above mentioned primary action on the sebaceous glands and hair follicles (6), and should therefore become progressively evident based on the physiological duration of growth and regrowth of shedded hair, thanks to the activity exerted by Kevis.

Nevertheless, the prompt improvement of the same parameters also suggests a direct and synergic action of the product's active ingredients (H.U.C.P., Thioglycoran, Thurfyl nicotinate, Biotin and Na-pantothenate) on the structure of the hair, mainly in terms of keratin synthesis stimulation.

In conclusion, a long-term cycle of applications with Kevis is to be considered as a very reliable approach to the local treatment of androgenetic alopecia. In fact, use of the preparation by both males and females, regardless of the actual alopecic pattern, was not only effective in a wide majority of cases (approx. 90%), but also practically devoid of any risk in terms of side effects.
Bibliography

1. Vignini M., Speziali A., Fideli D., Donadini A.: Azione sul cuoio capelluto di un prodotto per uso topico. La Med. Estetica, Anno 10, n° 4, pp 97-100 (1986).

2. Pelfini C., Fideli D., Speziali A., Vignini M.: Effects of a topical preparation on some hair growth parameters, evaluated utilizing a morphometric computerized analysis. Int. J. Cosm. Sc., 9, pp 1-11 (1987).

3. Dallera F., Grazia D., Grossi F., Venafra R.: Studio in doppio cieco contro placebo nel trattamento del telogen effluvium del post partum: La Med. Estetica, Anno 12, n° 3, pp 1 129 (1988).

4. Epifani C., Alberio F., Gini., Scognamiglio G., Venafra R.: Relazione sul trattamento col topico denominato "Kevis" su colontari affetti da neoplasia e sottoposti a cicli di chemioterapia mediante farmaci citostatici. La Med. Estetica, Anno 12, n° 1, pp 29-36, (1988).

5. Privat Y.: A double-blind placebo-controlled study with Kevis Lotion. Trends in Human Hair Growth and Alopecia Research, Kluwer Academic Pub., pp 231-245 (1988).

6. Berardesca E., Miori L., Rabbiosi G., Venafra R.: Valutazione dell'attività anti-androgena dell'H.U.C.P.. Abstract, lères Journées, Soc. Int. de Cosmétologie Médicale et Pharmaceutique, 18-19 Maggio 1990, Marsiglia.

7. Lucky A. W.: The paradox of androgens and balding: where are we now? J. Inv. Dermatol. (1988).

8. Sawaya M. E., Honig L. S., Garland L. H., Hsia S. L.:~ -5-3~-Hydroxysteroid dehydrogenase activity in sebaceous glands of scalp in male-pattern baldness. J. Inv. Dermatol. (1988).

9. Cipriani C.: Evaluation of the trichology activity of a preparation containing GAGS and retinoic acid compared with a minoxidil solution. Congr. Int. di Dermatol., Berlino, (1988).

10. Messenger et al.: Distribution of proteoglycans during the human hair growth cycle. Abstract, J. lnv. Derm., Vol. 92, n° 3, pp 540 (1989).

11. Hamilton J.B.: Patterned loss of hair in man: types and incidence. Ann. NY Acad. Sci. 53, pp 708-728, (1952).

12. Ludwig E.: Classification of the types of androgenic alopecia (common baldness) occuring in the female sex. Br. J. Dermatol., 97, pp 247-254 1977).

13. Baden H.P.: Diseases of the Hair and Nails, pp 118. Year Book Medical Publishers Inc. (1987)

14. Berardesca E., Gabba P., Borroni G., Rabbiosi G.: Assessment of the effects of a topical product containing glycosaminoglyclans in cutaneous hydration. lnt. J. Clin. Pharm. Res., Vlll (1), pp 69-73 (1988).

More Kevis information can be found on the pages below:

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Re: Kevis the World's Most Expensive Shampoo Cures Baldness

Post by hapyman » Wed Oct 14, 2009 10:18 am

Interest the listed ingredients over at the Kevis site lists Hyaluronic Acid but then H.U.C.P. right after in parenthesis.
Water, SD Alcohol 40-c+SD Alcohol 3-c, Propylene Glycol, Hydolized Glycosaminoglycans (Thioglycoran), Panthenol, Sorbic Acid, Methylparaben, Hyaluronic Acid (H.U.C.P.), Thurfylnicotinate HCL, Propylparaben, Sodium Hydroxide, Biotin, Fragrance.

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Re: Kevis the World's Most Expensive Shampoo Cures Baldness

Post by hapyman » Wed Oct 14, 2009 10:25 am

Can't find much on HUCP except that it is a naturally occurring complex found in umbilical cords. The only other abbreviation I could find that was similar was "Human Uncoupling Protein".

Here is their patent but not much there about HUCP.

Patent: Method of treating dermatological conditions
b) HUCP, a natural complex extracted form the human umbilical cord, containing approximately 600 mg/cl of hyaluronic acid with a relative molecular mass of 2.8 million. Other substances present in HUCP are proteoglycans, glycoproteins, and polypeptides.

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Re: Kevis the World's Most Expensive Shampoo Cures Baldness

Post by hapyman » Wed Oct 14, 2009 10:28 am

Here is more information:
Kevis Hair Improvement Program and HUCP

Along with being drug-free and devoid of harsh detergents, both of which harm one's body and one's hair, Kevis products have a primary technical advantage in handling hair loss and hair care.

Hyaluronic acid, the main active ingredient in Kevis Extra Strength Hair and Scalp Lotion and all Kevis products, is known to promote strength and fortitude at the cellular level.

Most prevalently located in the eyes, joints (especially the synovial fluid of the knees), and head of human sperm, hyaluronic acid is directly responsible for cellular hydration and viscosity.

Kevis’ patented HUCP is a high-molecular-weight version of hyaluronic acid and is our proven solution for fighting DHT, the primary cause of male-pattern hair loss.


Image
Source: Institute of Clinical Dermatology
University of Pavia

HUCP’s high-molecular-hyaluronan formulation allows it to be topically applied and subsequently penetrate deep into the scalp where it fills follicle receptor sites where DHT normally attaches to the hair follicle.

When DHT attaches to hair follicles in its usual way, it chokes off the hair-producing dermal papilla, inhibiting hair growth and eventually causing the follicle to lay dormant and, if left untreated for too long, completely killing it.

Through the application of the Kevis Hair Improvement program, your hair follicles become inundated with hydrating HUCP that block DHT from follicular receptor sites and back into the bloodstream as they are carried away by the body as waste.



Once HUCP has reached a point of critical mass in the dermis of the scalp, hair follicles remain protected. This allows your hair to grow in its natural way, undisturbed by constant bombardment of DHT molecules.

On a molecular level, HUCP tricks the follicular receptors into thinking that it is DHT. This is because hyaluronic acid, HUCP, and DHT all have similar chemical bonds which are the specific parts of each molecule that are received by follicular receptors.

By leveraging your body’s natural biochemistry, Kevis products and the Kevis Hair Improvement program actively reduce DHT levels in your scalp on a follicular level, allow your hair to flourish in its inherent way.

Kevis Booster

Our new Kevis Booster takes the war on DHT to another level by directly engaging and attacking it.

The offensive launched by Kevis Booster on DHT occurs through a process of natural protein interaction. Kevis Booster is an engineered protein known as an enzyme that actually breaks DHT molecules apart before they can even reach the hair follicle.

By using a protective layer of phospholipids, the super-penetrating Kevis Booster plunges beneath the dermis and comes upon DHT in the scalp, on its way to hair follicles. Kevis booster enzymes latch onto DHT molecules at the same chemical bond they use to attach to follicular receptors. The enzymes digest the DHT chemical bond and break it into two lower form steroids (naturally present in your body). These chemical compounds, like HUCP-blocked DHT, are similarly eliminated by the body as waste.

Again, through natural advantage on a molecular level, Kevis products take the fight against DHT and hair loss to a completely new level.

ImageImageImage

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Re: Kevis the World's Most Expensive Shampoo Cures Baldness

Post by Jacob » Wed Oct 14, 2009 1:54 pm

By using a protective layer of phospholipids
So it's liposomal :-k

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Re: Kevis the World's Most Expensive Shampoo Cures Baldness

Post by hapyman » Wed Oct 14, 2009 6:22 pm

I found it interesting that Hyaluronic Acid was so similar to DHT in structure. A guy over IHs is having some progress using a mixture of HA and Papain. Wondering if HA may act as a direct competitor of DHT at the receptor site by itself.

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Re: Kevis the World's Most Expensive Shampoo Cures Baldness

Post by Jacob » Wed Oct 14, 2009 6:44 pm

I know topical Papain was big topic years ago at Hairsite. Never tried it myself. I'm assuming he's using it for it's anti-fibroness? That reminds me..there's a topical I'm supposed to keep using that's made for that. :-s

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Re: Kevis the World's Most Expensive Shampoo Cures Baldness

Post by 0416Dr » Wed Oct 14, 2009 11:33 pm

Jacob, are you serieus about this product or is this some kind of a joke? That picture of that guy looks....how do you say it....TOO impressive....
I went to buy a camouflage jacket the other day but I couldn't find any.

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Re: Kevis the World's Most Expensive Shampoo Cures Baldness

Post by Fizzball » Thu Oct 15, 2009 6:28 am

This is impressive, I'd actually be whiling to try it out but it seems like they only accept credit cards and I don't have one... what a let down :|

I sent them an email about the situation and will hopefully find out soon, I'll let you guys know if I get on the stuff ;)
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Re: Kevis the World's Most Expensive Shampoo Cures Baldness

Post by Jacob » Thu Oct 15, 2009 6:34 am

0416Dr wrote:Jacob, are you serieus about this product or is this some kind of a joke? That picture of that guy looks....how do you say it....TOO impressive....
Not any more serious than anything else I post about..I guess. Just posting it for the info/discussion. It's something I wouldn't mind trying..someday.

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Re: Kevis the World's Most Expensive Shampoo Cures Baldness

Post by hulihoop » Thu Oct 15, 2009 8:27 am

I find it interesting that on the Kevis site they talk about clearing out the follicles which are "clogged" with DHT which sounds a lot like the approach Steve is talking about re Scalpure. Having said that I do see the differences: different science, different explanation of process, and most notably Kevis is not here selling their product. Still...

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Re: Kevis the World's Most Expensive Shampoo Cures Baldness

Post by hapyman » Thu Oct 15, 2009 9:10 am

Jacob wrote:I know topical Papain was big topic years ago at Hairsite. Never tried it myself. I'm assuming he's using it for it's anti-fibroness? That reminds me..there's a topical I'm supposed to keep using that's made for that. :-s
According to IH papain can also be a little estrogenic (? can't remember exactly what he said), which is good for hair. But yeah mainly papain is used to reverse the damage done by MPB. A couple of the guys are using EOD or just a couple times a week, which is probably smart for a proteolytic enzyme as potent as papain. This got me thinking that if you could reverse and ward off the negative effects of MPB stuff like DHT just wouldn't matter.

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Re: Kevis the World's Most Expensive Shampoo Cures Baldness

Post by cld » Thu Oct 22, 2009 5:01 pm

hey guys!! i had to reregister because i couldnt retrieve my password. i've emailed the site admin but still have not recieved an updated response..

anyhow this papain sounds interesting.. can anyone direct me to some studies or something? i know "google"just thought that somebody might have them. also what brand of papain are people using and how?

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