Accolate or Singulair for hair loss and/or acne????

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Tricia
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Accolate or Singulair for hair loss and/or acne????

Post by Tricia » Thu Jul 29, 2004 11:49 am

I saw this pharmacy patent filed recently. It investigates using Accolate for acne, rosacea, and hair loss. Well, I would be happy if it worked on both. I do suffer from adult acne and some hair loss. But, I'm skeptical. It seems as if it did work, then a bunch of people who used these drugs for asthma would start jumping up and down about how nicely their skin cleared up and how they were growing more hair. For what it's worth, here's the patent info...kind of long......


Title: Method of treating hair loss
United States Patent: 6,762,193
Issued: July 13, 2004
Inventors: Sanders, Jr.; Richard J. (77173 Highway 21, Covington, LA 70453)
Appl. No.: 228508
Filed: August 27, 2002
Abstract
A method of treating inflammatory skin diseases and/or hair loss, comprising administering to a patient in need of such treatment a therapeutically effective amount of a leukotriene receptor anatagonist, an antihistamine, or other anti-inflammatory drug, preferably at least twice a day, preferably for at least two months.
BRIEF SUMMARY OF THE INVENTION
A method of treating acne and other inflammatory skin diseases is provided which comprises administering to a patient in need of treatment an anti-leukotriene or antihistamine agent, or other anti-inflammatory agent alone or in combination, preferably twice a day, preferably for at least two months.
DETAILED DESCRIPTION OF THE INVENTION
Current treatment outcomes in patients with acne vulgaris are not consistent nor fully explained with present day therapy. Immunological factors appear to play a more important role than previously recognized. Because acne is an inflammatory skin disease, we investigated the use of anti-inflammatory agents on the treatment of acne. The anti-inflammatory agent we investigated most fully included the anti-leukotriene, zafirlukast.
With the onset of puberty and under the direction of androgenic hormones sebaceous glands enlarge secondary to increased triglyceride formation. Triglycerides are then hydrolyzed to free fatty acids by the enzyme hyaluronidase from p. acnes. With the release of hyaluronidase by p. acnes, hyaluronic acid present in cell coats breaks down. Free fatty acids are not truly immunogenic by themselves but become so by virtue of their chemical reactivity with self skin proteins thereby creating larger conjugates.4 Increasing complexity as well as host genetic factors contribute to a molecules immunogenicity. In the presence of this free fatty acid moiety, or immunogen, cell surface antibodies or immune system cells become reactive, triggering the release of leukotrienes, histamines, and other vasoactive substances. Tissue congestion occurs compromising the orifice of the pilosebaceous complex ultimately creating an impaction at the follicle. The microcomedo, or acne precursor lesion, is the resultant product of this process. Extravasation of the contents of the pilosebaceous unit into the surrounding dermis results in the inflammatory acne lesion. Eventually, follicle walls rupture and acne nodules develop. Supportation of the acne nodule results in the acne cyst.
Because the inflammatory response of the acne lesion is mediated by the release of leukotrienes, and histamines, then the introduction of anti-leukotrienes and/or antihistamines will effectively prevent the formation of new acne lesions and exert a significant impact on the resolution of old lesions.
Anti-leukotrienes are a topic of great interest at the present time. Leukotriene (LT) synthesis begins with phospholipase A2 mediated conversion of phosphatidyl choline from the nuclear membrane to arachidonic acid. Arachidonic acid binds to 5-lipoxygenase (5-LO) activating protein (FLAP) effectively increasing its concentration in the vicinity of the 5-LO enzyme. Arachidonic acid is then converted to leukotriene A4 (LTA4). LTA4 may then be converted to the chemotaxin LTB4, or, in sequential steps to LTC4, LTD4, and LTE4. LTC4, LTD4, and LTE4 are the cysteinyl leukotrienes.
There are two types of anti-leukotriene agents, LT synthesis inhibitors and LT receptor antagonists. Zafirlukast is an anti-leukotriene that competitively inhibits the binding of leukotriene D4 at its receptor site. Currently, the medical applications of zafirlukast is in the prophylactic treatment of patients with mild to moderate asthma.5 Zafirlukast alone has already become established as the standard of care in long term asthma management in both adolescence and adults, and is now indicated for use in the pediatric population aged seven and above. Results of other studies suggest efficacy in the treatment of leprosy reaction,14 migraine prophylaxis11, atopic dermatitis2 and chronic urticaria.12
It is important to note that zafirlukast (such as Accolate.RTM.) is a selective and competitive receptor antagonist of leukotriene D4 and E4 components of slow reactive substances of anaphylaxis. Zafirlukast is a member of a class of drugs initially called the LTD4 -receptor-antagonists. These drugs are now named the CysLT1 -antagonists to "recognize that each of LTC4, LTD4 or LTE4 is a potential natural agonist at their common receptor in human airways"9. Zafirlukast inhibits leukotriene formation by competitively inhibiting the binding of leukotriene D4 at its receptor site; it does not inhibit the formation of leukotriene B4 Because leukotriene B4 is relatively high up in the cascade of events leading to the synthesis of the cysteinyl leukotrienes (LTC4, LTD4, and LTE,4), blocking leukotriene B4 formation can cause more general and significant deleterious side effects not seen by more specific targeting of the downstream leukotrienes LTC4, LTD4, and LTE4 as is the case with zafirlukast
EXAMPLE #1
This study was designed to evaluate the effectiveness in treating acne vulgaris with the drug zafirlukast After having established a mechanism by which zafirlukast would be effective in the treatment of acne vulgaris, and subsequently treating a single case of acne conglobata successfully during the summer and fall of 1999, this study was purposely designed to evaluate the treatment of acne vulgaris with the drug zafirlukast
Objective: To determine if the anti-leukotriene zafirlukast is effective in the treatment of acne vulgaris/acne rosacea.
Design: Inception cohort investigational study conducted from October 1999 to January 2000.
Setting: Rural Family Practice clinic in Waldheim, La.
Participants: A total of 7 male and 8 female patients aged 12-45 years diagnosed with mild, moderate, or severe acne vulgaris including one case of acne conglobata and 2 cases of acne rosacea were given 20 mg. of zafirlukast (ACCOLATE.RTM. brand from AstraZeneca) twice daily from week 1 through week 4. The dose was increased to 30 mg. twice daily at week 4 and continued through week 8. At week 8 the dose of zafirlukast was decreased to 20 mg twice daily and continued until the termination of the study at 10 weeks.
Between the months of October and November 1999 both adolescent and adult patients were recruited consecutively at a family practice clinic in rural Louisiana to participate in an investigational study to determine the effectiveness of zafirlukast in the treatment of acne vulgarism Those patients who provided informed consent and who have reported a prior medical diagnosis of acne vulgaris were enlisted into the study. This cohort was composed of a total of seven male and eight female Caucasian patients, age twelve to forty five years, diagnosed with mild, moderate or severe acne vulgaris.
Pre-study recruitment assessment data was consistent with the following: one of fifteen patients was diagnosed with acne conglobata; two of fifteen patients were diffused with acne rosacea, one of which had acne scars who had previously been treated with oral isotretinoin for nodular-cystic acne; eleven of fifteen patients with moderate to severe inflammatory/nodular-cystic acne; all patients had self medicated with topical comedolytic over-the-counter agents; three of fifteen patients had never been treated with prescription (topical or systemic) medications; twelve of fifteen patients were prescribed a range of three to five medical prescriptions (both topical and systemic) with varying degrees of success and failure; three of fifteen patients had previously taken oral isotretinoin; two of fifteen patients had been offered oral isotretinoin but refused that treatment.
Inclusion criteria for study enlistment encompassed any patient who was requesting medical treatment of a chief complaint of acne dermatitis, coincident with a clinical diagnosis of acne vulgaris confirmed by physical examination. These patients voluntarily agreed to be treated with zafirlukast knowing that alternative treatment (both topical and systemic) were available. At the initial visit all patients were instructed on the use of zafirlukast This was to be administered by mouth twice daily. The potential side effects, potential adverse reactions, and other risks were all explained. Patients all agreed to avoid any over-the-counter acne preparations and were to use any household soft-soap product to wash the facial skin twice daily. Zafirlukast was to be administered at the dose of 20 mg. twice daily from week one through week four and then to be increased to 30 mg. twice daily at week four and continued through week eight. At week eight the dose of zafirlukast was to be decreased to 20 mg. taken twice daily and continued until the completion of the study at ten weeks.
Main Outcome Measures: Subjective and objective medical examination and qualitative photographic analysis were employed at each patients initial visit to establish baseline. Thereafter, each patient was consecutively examined and photographed at two to three week intervals. At each respective visit, treatment benefits were assessed, compliance was questioned, and side effects, if any, noted. Patient satisfaction was measured by having all participants complete a post study survey. This questionnaire allowed patients to document adversities or side effects, self-esteem improvement, diminution of facial pain and discomfort, and overall satisfaction with the course of treatment. Data was utilized from primary care visits at the Waldheim Family Practice Clinic.
Results: All fifteen patients finished the study and completed the post study survey. Significantly, all participants attained periods of acne remission during the study. Subjective and objective clinical improvement was observed as early as two weeks, but routinely occurred within 3-4 weeks of initiating zafirlukast therapy. All cases of mild, moderate, or severe acne vulgaris studied including acne rosacea, acne conglobata, and nodulocystic acne responded similarly in their observed periods of remissions or exacerbations. The data were correlated with qualitative photographic analysis. Satisfaction ratings in the post study survey were high and most patients preferred to continue zafirlukast alone or as combination therapy with other comedolytic or anti-infective agents.
In so much as there was a continual decline in both inflammatory and non-inflammatory acne lesions during this study, patient self-esteem progressed and appeared to improve by week four, and matured by week eight, only falling off slightly during periods of acne recurrence. Remission of acne vulgaris, characterized by the absence of new lesion formation, old lesion regression and the observed decline in perilesional erythema and facial discomfort, were all factors contributing to the amelioration of patient self-esteem.
Only one patient was compliant in taking zafirlukast throughout the entire study. He was able to maintain complete remission and accomplish total regression of any inflammatory acne lesion. He experienced only a mild facial erythema for two days following the dosage drop from 30 mg to 20 mg.
However, it was not uncommon for patients to miss anywhere from two to three consecutive doses in any one week and six patients had significant dosage discontinuation each at nine, seven, six, five, and two at three consecutive days, respectively. One patient who missed three consecutive days also missed every weekend throughout the entire study. Only one person requested referral to dermatology at the termination of the study. Data analysis revealed that he was one of two participants consistently non-compliant throughout the entire study. It should be noted, however, that medical noncompliance is not a quite uncommon finding during the management of a chronic medical condition during any study and does not reflect the success of the treatment. For example, in this study, factors that contributed to non-compliance include the twice daily dosing requirements, a false sense of well being once remission was realized, the mere fact that most patients whom were non compliant were in the study group compromising those in the teenage years and usually took weekend a retreat from their homes and the guidance of their parents whom were directing their therapy to some degree. There were also those who were content with the remission of new lesions and less inclined to be concerned with the regression of old acne lesions.
Those who were consistently non-compliant had acne reoccurrence within 2-3 days after more than 2-3 doses missed. Discontinuation of zafirlukast therapy over a 5-7 day period was associated with reoccurrence of acne form lesions equal to baseline levels. However, reinstitution of zafirlukast therapy was associated with old lesion regression and new lesion remission, commonly occurring within a period of time resembling the duration of zafirlukast deprivation. There appeared to be no added benefit observed in taking 30 mg. twice daily from week 4 thru week 8.
Although perilesional erythema appeared to resolve only by approximately 10-15% by week two, significant reductions of 40-50% and 80-90% were achieved by weeks four and eight respectively. Remarkably, there was little if any perilesional erythema accompanying the development of any new inflammatory acne lesion that developed while any patient was taking zafirlukast.
One participant who suffered with acne rosacea felt a sense of asthenia in taking zafirlukast on an empty stomach, thereafter she continued the study from week two through, week ten at 10 mg. dosage levels twice daily with no further side effects observed. She was the only participant whom ever realized any potential side effects while being treated with zafirlukast.
Conclusion: This study substantiates efficacy in modifying the inflammatory reaction of acne vulgaris Zafirlukast exerts a potent therapeutic effect on the acne process and plays a pivotal role in the prophylactic management of acne vulgaris. The recommended dosage of zafirlukast for adults (.gtoreq.12 years) is 20 mg twice daily; for pediatrics (7-11 years) the recommended dosage is 10 mg twice daily. The preferred daily dosage range of zafirlukast for adults (>12 years) is about 20 mg twice daily; for pediatrics (7-11 years) the recommended dosage is about 10 mg twice daily. It is preferably taken twice daily or administered in a form that it is released into the bloodstream twice daily. It is preferably taken consistently for at least 4 weeks, more preferably at least 8 weeks, and even more preferably at least 12 weeks. Most preferably, it is taken every day without stopping. The method of the present invention is most effective if zafirlukast is taken as prescribed every day. Additional controlled studies, such as double blind placebo studies, increasing drug dosage at the onset and throughout entire length of study, prolonged study periods and study protocols that would include anti-leukotriene therapy side by side with comedolytic anti-infective, anti-histamine and anti-androgen therapies will demonstrate the significant value of zafirlukast in patients who suffer from this dreadful disease.
Other Effective Treatments Encompassed by the Present Invention
In addition to zafirlukast, the following drugs will also be effective in treating acne and other inflammatory skin diseases.
Montelukast (such as Singulair.RTM.) is another leukotriene blocker. Singulair was tested and shown to be effective. It is a selective and orally active leukotriene receptor antagonist that inhibits the cysteinyl leukotriene receptor. The recommended dosage for adults (.gtoreq.15 years) is 10 mg in the evening; for pediatrics (6-14 years) the recommended dosage is 5 mg in the evening.
Leukotriene inhibitors (such as cromolyn sodium) will also work, but may be less desirable as they may have harmful side effects. Cromolyn sodium acts by inhibiting the release of histamine and leukotrienes from the mast cell. In vitro and in vivo animal studies show that cromolyn sodium inhibits synthesized mast cell degranulation that occurs after exposure to specific antigens. Cromolyn sodium acts by inhibiting the release of mediators from mast cells. Studies show that cromolyn sodium directly blocks calcium ions from entering the mast cell thereby preventing mediator release. Cromolyn sodium inhibits both the immediate and non-immediate bronchoconstrictor reactions to inhaled antigens. Cromolyn sodiun also attenuates bronchospasm caused by exercise, aspirin, cold air, sulfur dioxide and environmental pollutants (see Physicians' Desk Reference page 987, 50th edition 1966).
Examples of commercially available cromolyn sodium are Gastrocrom.RTM., Intal inhaler.RTM., Intal nebulizer solution, Opticrom Ophthalmic solution and cromolyn sodium inhalation solution USP. The recommended dosage of Gastrocrom.RTM. for adults (13+) is two 100 mg ampoules taken orally 4 times per day (800 mg daily total), 1/2 hour before meals and at bedtime, and for children 2-12, one 100 mg ampoule taken orally 4 times per day (400 mg daily total), 1/2 hour before meals and at bedtime.
Zileuton (such as Zyflo.RTM.) is an oral active inhibitor of 5-lipoxygenase, the enzyme that catalyzes the formation of leukotriene from arachidonic acid. The recommended dosage for adults (.gtoreq.18 years) is 600 mg four times per day (2400 mg daily total).
Histamines play some role in acne formation, and antihistamines administered daily will help reduce acne formation. Preferred antihistamines include loratadine (e.g. Claritin.RTM.), ranitidine (e.g. Zantac.RTM.), cimetidine (e.g. Tagamet.RTM.), famotidine (e.g. Pepsid.RTM.), nizatidine (e.g. Axid.RTM.), and fexofenadine (e.g. Allegra.RTM.), hydroxyzine HCl (e.g. Atarax), cyprohepadine (e.g Periactin), promethazine HCl (e.g. Phenegan), cetrizine (e.g. Zyrtec), and hydroxyzine pamoate (e.g. Vistaril) because they do not sedate. However, other antihistamines would work as well. It is believed that antihistamines administered daily may help reduce acne formation if taken for 2 months or longer.
Loratadine is especially preferred due to its dual action of acting as an antihistamine and as a leukotriene C4 antagonist
Examples of Antihistamines Useful in the Present Invention:
A. Histamine H1 -receptor antagonist compounds that can be used in the method of the present invention include those listed in the Physicians Desk Reference (2000 ed.) under the following product categories in the blue pages on page 204, etc.: 1) antihistamines and combinations; 2) also see under nasal preparations--antihistamines; and 3) ophthalmic preparations--antihistamines and combinations.
B. Histamine H1 -receptor antagonist compounds that can be used in the method of the present invention include those corresponding to the ones listed in A above which are listed in the nonprescription P.D.R. (2000 ed.).
C. Histamine H2 -receptor antagonist compounds that can be used in the method of the present invention include those listed in the Physicians Desk Reference (2000 ed.) on page 210.
D. Histamine H2 -receptor antagonist compounds that can be used in the method of the present invention include those corresponding to the ones listed in C above which are listed in the nonprescription Physicians Desk Reference (2000 ed.).
The method of the present invention will also work for sebaceous cysts as well as acne.
If no dosages are listed herein for a particular drug, the dosage recommended for treatment of asthma can be used.
Hair Loss Treatment Method
INTRODUCTION
The significance of inflammation in acne pathogenesis is well described in the literature over the past several decades. In as much as it has been clinically proven that the inflammatory reaction associated with acne vulgaris, and rosacea resolves in patients taking zafirlukast, which competitively antagonizes the cellular receptor for cysteinyl leukotrienes, the cyst LT 1 receptor7., there is still no adequate explanation as to why patients suffering from these dreaded diseases develop a state of remission while taking this drug. Having considered the research data presented thus far, several questions still remain. Considering the fact that acne vulgaris is androgen mediated, does zafirlukast exhibit antiandrogen activity, and if so, would this drug have any benefit in treating other diseases know to be mediated by antrogens? In an attempt to answers these questions, further study was undertaken to determine whether or not a biological marker exists that would explain our findings and if so would current and past scientific investigation support our conclusion.
DISCUSSION
STUDY
During the summer of 2000 an investigative study was initiated to determine the efficacy of zafirlukast in the treatment of androgenetic alopecia A middle aged 40 year old blond haired caucasian male whom was actively undergoing genetically influenced alopecia was recruited and voluntarily enlisted into the study under informed consent. Prior to taking zafirlukast this patient had never received treatment for androgenetic alopecia and physical examination showed no evidence of pathological hair loss. Zafirlukast was initiated at a dose of 20 mg taken twice daily and within the first 6 weeks of zafirlukast treatment both the patient and his wife witnessed less occurrence of hair loss and by the fourth month of treatment regrowth of hair in the area of temporat and vertex balding was observed. Serum ancillary studies obtained at the completion of his fourth month of zafirlukast therapy revealed a dihydrotestosterone level of 32 NG/DL (normal 25 to 75 NG/DL). Just two months earlier serum luteinizing hormone, total testosterone, androstenedione and dehydroepiandrosterone sulfate levels were determined to be normal. Having considered that dihydrotestosterone levels may have been suppressed to a low normal range, as pre treatment dihydrotestosterone serum determination had not been performed, the dose of zafirlukast was increased to 40 mg taken by mouth twice daily. Continuing this dose for a one month period of time, serum dihydrotestosterone levels were reanalized and determined to be 21 NG/DL (normal 25 to 75 NG/DL). Additionally, serum 3-alpha androstanediol glucuronide, estrone, androstenedione, total testosterone, prostate specific antigen, and progesterone levels were within normal limits at this time. The patient was then withdrawn, from zafirlukast therapy and there were no specific complications or side effects during a one month abstinence from zafirlukast and serum dihydrotestosterone levels were redetermined and found to be 15 NG/DL (normal 25 to 75 NG/DL). This patient was then given the option to continue treatment with zafirlukast at a dose of 40 mg taken by mouth twice daily for the treatment of androgenic alopecia and decided to do so as he had witnessed the continued regrowth of hair and remission of hair loss while taking zafirlukast. There were never any side effects observed while he was taking zafirlukast In an attempt to verify and cross reference these significant findings with a male patient undergoing treatment with zafirlukast for acne vulgaris and a female patient whom enlisted into a study to determine the effects of zafirlukast on hereditary balding and whom had previous treatment failures with finasteride, blood serum analysis was performed to determine whether or not dihydrotestosterone suppression was also occurring in these individuals as well. The results are as follows:
In a 19 year white male undergoing treatment for Grade IV cystic acne vulgaris with zafirlukast at 40 mg po bid (by mouth twice a day) for 4 weeks, preceded by 2 weeks of zafirlukast treatment at 30 mg bid, his serum dihydrotestosterone level was determined to be 16 NG/DL (normal was 25 to 75 NG/DL).
In a 53 year old white female undergoing treatment with zafirlukast at 40 mg po bid for hereditary balding, her pretreatment dihydrotestosterone level was 5 NG/DL (normal 5 to 30 NG/DL); after 4 weeks of continuous treatment her dihydrotestosterone serum concentration was 4 NG/DL (normal 5 to 30 NG/DL) and at 6 weeks of continued treatment her serum dihydrotestosterone level was determined to be less than 3 NG/DL.
In both of these individuals not only was dihydrotestosterone suppression realized but a significant improvement in acne lesion remission and clearing in the male individual and regrowth of frontal hair in the female individual was documented. Both individuals continued medical treatment and management of their respective illnesses under informed consent never witnessing any side effects or adversities and are pleased with their outcomes thus far.
DISCUSSION
For many years medical researchers have studied the pathways of androgen metabolism and have recognized its undesirable consequences i.e., acne vulgaris, androgenetic alopecia, idiopathic hirsutism and benign prostatic hypertrophy, besides others. There now appears to be significant evidence to suggest that in some individuals the drug zafirlukast not only blocks the potent inflammatory reaction mediated by leukotrienes, but also possess antiandrogen activity as well.
In this study a dose and time dependent effect has been identified with the treatment of both acne vulgaris and common baldness in genetically susceptible men and women without physical or psychological compromise, or forfeit of quality of life. The use of zafirlukast in treating these dreaded diseases appears to be safe and effective at doses above those recommended for the treatment of asthma as shown in this study. Serum liver function studies monitored during this study remained in the normal range of value except in one patient with known Hepatitis C and abnormal pretreatment liver function studies; however, in all patients including the one patient with Hepatitis C, serum liver function studies improved with zafirlukast treatment possibly indicating a role in treating liver diseases in the future.
There are several biological mechanisms that could be implicated in explaining the results of this study including the following:
A) By inhibiting the action of 5-alpha reductase or 17 beta-hydroxysteroid dehydrogenase, the two principal pathways of testosterone metabolism in all growing hairs and skin cells7.
B) By inhibiting the formation or action of the metabolite of testosterone or androstenedione i.e. dihydrotestosterone, 5-alpha androstanediol, 5-alpha androstanedione, 5-alpha androsterone or estrone7.
C) By inhibiting the peripheral conversion of androstenedione to testosterone in the skin7.
D) By inhibiting adenyl cyclase due in fact to high dihydrotestosterone levels in the hair follicle(high dihydrotestosterone levels in genetically marked hair follicles initiate baldness by inhibiting adenyl cyclase)7.
E) By alteration of the androgen receptor protein in the peripheral target cells allowing them to concentrate androgens at the presumed site of action in the cell nucleus i.e., interception, antagonism, or inhibition of the highly specific antrogen receptor protein that binds with dihydrotestosterone and transports it to the cell nucleus7.
F) By blocking dihydrotestosterone at a given target site7.
G) By promoting the formation of progesterone7.
H) By promoting the formation of steroids all having structural resemblance to testosterone and thus competing with testosterone for the binding site on the enzyme 5-alpha reductase i.e., 4 androsten-3-one-17 beta-carboxylic acid, androstenedione and deoxycorticosterone7.
CONCLUSION
Zafirlukast is both safe and effective in the treatment and management of inflammatory and androgen mediated disorders for which dihydrotestosterone suppression and leukotriene antagonism is desired. Although more rapid and sustained effects are produced at elevated dosage levels, adequate disease resolution occurs at doses not associated with serum dihydrotestosterone suppression below the lower limits of normal relative to one's age or sex, suggesting that a dual mechanism of action exist for zafirlukast i.e., antileukotriene and antiantrogen effects. This new found idea and discovery will help strengthen our understanding of treating acne vulgaris, androgenic alopecia, female hereditary balding and other androgen or leukotriene mediated illnesses and in fact may change our way of thinking and approach to these significant illnesses whose symptoms and disease characteristics are ameliorated with the use of zafirlukast. Additional research and development of the drug zafirlukast is recommended at this time.
All measurements disclosed herein arc at standard temperature and pressure, at sea level on Earth, unless indicated otherwise. All materials used or intended for use in a human being are biocompatible, unless indicated otherwise.
Claim 1 of 8 Claims
What is claimed is:
1. A method of treating hair loss disorders, comprising administering to a subject in need of such treatment a therapeutically effective amount of a leukotriene receptor antagonist wherein said leukotriene D4 receptor antagonist is selected from the group consisting of zafirlukast and montelukast.

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HairLossFight.com
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Hair Loss Type: Androgenetic Alopecia (Male Pattern Baldness)
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Post by HairLossFight.com » Tue Sep 07, 2004 9:53 pm

My_username,

Any new word on this?

Regards,
Sam

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Tricia
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Posts: 325
Joined: Thu Jun 03, 2004 5:19 am
Hair Loss Type: Don't Know
Have you had a hair transplant?: No

no new word

Post by Tricia » Wed Sep 08, 2004 5:50 am

I posted this on another web site and didn't get any responses. It seems as if no one takes Singulair or Accolate.

I think I will get a prescription for one of these and see for myself. It will be kind of hard for me to get a prescription, since I don't have asthma or bad allergies.

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HairLossFight.com
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Posts: 1218
Joined: Sun Aug 24, 2003 3:24 am
Hair Loss Type: Androgenetic Alopecia (Male Pattern Baldness)
Norwood Level: Norwood III Vertex
Have you had a hair transplant?: Yes

Post by HairLossFight.com » Wed Sep 08, 2004 9:40 am

Just make sure you're careful! You'd probably have to use the stuff for quite a while to see if it works. If I were you I wouldn't try it.

Regards,
Sam

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