DermaHeal discount(15%) code

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Re: DermaHeal discount(15%) code

Post by Pete2 » Tue Aug 25, 2009 10:01 pm

ChuckP wrote:Jacob
I ordered to bottle already, were do you go for the 15% off discount?

You might get results combining the topical with a Piroctone Olamine shampoo.



Regards
Pete

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Re: DermaHeal discount(15%) code

Post by intricate1 » Wed Aug 26, 2009 11:40 pm

So I am on the 3 rd day and sometimes I use it 2 times aday. Hair feels thicker and scalp feels smoother. The thickness is good if it's happening inside the follicle . Hair sheds when I rub hard under tge showe will keep u guys posted

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Re: DermaHeal discount(15%) code

Post by intricate1 » Thu Aug 27, 2009 12:25 pm

Anybody results?

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Re: DermaHeal discount(15%) code

Post by Jacob » Thu Aug 27, 2009 3:19 pm

Got a response from them:
The product should be stored at room temperature; in a cool, dry, place
with no direct exposure to sun light. Keeping it in a refrigerator will
not add to its shelf life.

We are going to have a new discount code for September, and as soon as the
promotion starts, we will let you know what the code and the discount is.
I'm not sure if the 15% off one no longer works or :?: Like I said..I'm waiting for things to cool down 8)

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Re: DermaHeal discount(15%) code

Post by cloud9 » Sat Aug 29, 2009 6:25 am

You can go to Amazon.com and buy DearmaHeal for $65 . Cheaper than the discount {15%} code offer .

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Re: DermaHeal discount(15%) code

Post by Jacob » Sat Aug 29, 2009 2:02 pm

But the discount makes it $63.75 :-s

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Re: DermaHeal discount(15%) code

Post by intricate1 » Sat Aug 29, 2009 5:13 pm

Just ordered the shampoo for 19 bucks on amazon the discount does not work for it, if it works and sales goes up other places will start carrying it and the price will go down. I am thinking about taking a dht blocker like sawpalmetto or shen min soy to help. I have a good feeling about all these topicals, they should just get better with time

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Re: DermaHeal discount(15%) code

Post by Jacob » Sun Aug 30, 2009 6:14 am

Are you using the topical? That would be my choice before the shampoo.

If you mean the discount doesn't work at the site mentioned here...they did say a new one is coming soon.

And competition is cool 8) Now if only those selling the Lamas serum would lower their prices. Maybe they aren't allowed to.

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Re: DermaHeal discount(15%) code

Post by intricate1 » Sun Aug 30, 2009 7:39 am

I got the shampoo because the serum does a great job in making my hair look great combined with the nourish shampoo from trader joes so iwanted to see what it does with the dermaheal shampoo, I'm happy to report temples have gotten smaller, hair is thicker only when the serum is on when taken off is thinner again, scalp feals smooth and the shed is still going

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Re: DermaHeal discount(15%) code

Post by kamisama » Sun Aug 30, 2009 8:04 am

Jacob wrote:Are you using the topical? That would be my choice before the shampoo.

If you mean the discount doesn't work at the site mentioned here...they did say a new one is coming soon.

And competition is cool 8) Now if only those selling the Lamas serum would lower their prices. Maybe they aren't allowed to.

i think we need gather people to get vitacost or swansons to carry lamas serum. btw, that 20% off code still work, i just ordered another today

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Re: DermaHeal discount(15%) code

Post by intricate1 » Sun Aug 30, 2009 6:40 pm

I think more people should try this and especially people who use 5ar inhibitors would see good regrowth

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Re: DermaHeal discount(15%) code

Post by Jacob » Sun Aug 30, 2009 7:11 pm

kamisama wrote:
Jacob wrote:Are you using the topical? That would be my choice before the shampoo.

If you mean the discount doesn't work at the site mentioned here...they did say a new one is coming soon.

And competition is cool 8) Now if only those selling the Lamas serum would lower their prices. Maybe they aren't allowed to.

i think we need gather people to get vitacost or swansons to carry lamas serum. btw, that 20% off code still work, i just ordered another today
You mean the 20% off for Lamas..right? I think I had gotten email that they extended the sale/discount to today. I had already ordered mine though :-s

I sent out quite a few emails to various places that carried the Lamas line. Either asking if they'd be carrying the new serum and if so, what will the price be...or for them to have a sale :!:

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Re: DermaHeal discount(15%) code

Post by intricate1 » Sun Aug 30, 2009 8:37 pm

Jacob wrote:
kamisama wrote:
Jacob wrote:Are you using the topical? That would be my choice before the shampoo.

If you mean the discount doesn't work at the site mentioned here...they did say a new one is coming soon.

And competition is cool 8) Now if only those selling the Lamas serum would lower their prices. Maybe they aren't allowed to.
Sorry guys what serum from lama?

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Re: DermaHeal discount(15%) code

Post by Jacob » Mon Aug 31, 2009 3:02 pm

intricate1 wrote: Sorry guys what serum from lama?
http://www.lamasbeauty.com/chinese_scalp_serum.html

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Re: DermaHeal discount(15%) code

Post by Jacob » Mon Aug 31, 2009 3:04 pm

Update on the discount for the Dermaheal:
Just wanted to let you know that we extended the 15%
discount promotion from Sep 1st to the Dec 31st. The discount code is
HL-0912.

We also have a promotion for bulk purchases of 10 serum or more for those
who are interested in stocking up this item. The discount is 25% off the
total price. If someone is interested, they need to contact Tanya.
I changed the code in the original post so there's no 'fusion.

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Re: DermaHeal discount(15%) code

Post by intricate1 » Mon Aug 31, 2009 4:19 pm

Jacob wrote:
intricate1 wrote: Sorry guys what serum from lama?
http://www.lamasbeauty.com/chinese_scalp_serum.html
Thanks Jacob this sound great I just don't know if I can apply it at the same time as the dermaheal. Dermaheal is helping the temples but it has not slowed the shedding but it has only been aweek and my temples are noticeably smaller

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Re: DermaHeal discount(15%) code

Post by intricate1 » Tue Sep 01, 2009 6:54 pm

glaxom wrote:I'm about 3wks in using it and yeah like mg i'm seeing some of those little hairs pop up in the frontal area which is the only area i'm applying it to.
Who knows if they are poppin up from massaging that area of the scalp while applying it or what...... or if they will just disappear when i stop using the product. Also this was the bottle that sat in my mailbox at 140degrees too so.................????


In other words i'm not sure what in the hell it's doing honestly, lol.
How are your results now?

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Re: DermaHeal discount(15%) code

Post by intricate1 » Thu Sep 03, 2009 6:51 pm

Gonna start the shampoo in combo with serum today

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Re: DermaHeal discount(15%) code

Post by Pete2 » Thu Sep 03, 2009 10:14 pm

intricate1 wrote:
Jacob wrote:
intricate1 wrote: Sorry guys what serum from lama?
http://www.lamasbeauty.com/chinese_scalp_serum.html
Thanks Jacob this sound great I just don't know if I can apply it at the same time as the dermaheal. Dermaheal is helping the temples but it has not slowed the shedding but it has only been aweek and my temples are noticeably smaller

To improve results add a shampoo that lowers inflammation.


Regards
Pete

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Re: DermaHeal discount(15%) code

Post by 1..... » Fri Sep 04, 2009 8:42 pm

any updates for dermaheal users?

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Re: DermaHeal discount(15%) code

Post by intricate1 » Wed Sep 09, 2009 10:23 pm

Scalp feels much better, right temple is smaller that is all I can say for now. I use the rogain foam in the mornings and the dermaheal shampoo and serum at night. I will keep u guys updated promise

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Re: DermaHeal discount(15%) code

Post by Pete2 » Thu Sep 10, 2009 9:24 pm

Jacob wrote:For those interested in trying it.

HL-0912

http://www.2weeksmiracleusa.com/store/i ... -loss.html

Edit..I guess the code doesn't work. I'll check back tomorrow.


Jacob /anyone

Anyone know what the ingredients list in Dermaheal is and LA science?

What are the differences between the two?

Jacob which peptide formula do you think you will add next if any?





Regards
Pete

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Re: DermaHeal discount(15%) code

Post by intricate1 » Fri Sep 11, 2009 12:16 am

It's on regrowth.com just google dermaheal hair concentrating serum it gives u a comparison on there if not I'll copy paste it later

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Re: DermaHeal discount(15%) code

Post by intricate1 » Fri Sep 11, 2009 6:12 am

Dermaheal
IGF-1(Insulin-like Growth Factor 1) - Reduce and prevent lines and wrinkles by actively generating new skin cells. - Increase collagen and elastin levels and reduce blotchiness. - Refine texture glides effectively and slim your face and body with a fat burning effect. - Strengthen hair while stimulating hair follicles to produce strong hair shaft.

bFGF (basic Fibroblast Growth Factor) - Reduce and prevent lines and wrinkles by actively generating new skin cells. - Involve in normal skin growth, healing and wound repair. - Strengthen skin elasticity by inducing the synthesis of collagen and elastin. - Help blood circulation in the scalp and revitalizing hair follicles.

Prohairin B4 - Increase cell growth and migration. - Promote hair growth by activating the stem cells of hair follicle. - More stable and prolong action than native proteins.

VEGF(Vascular Endothelial Growth Factor) - Hair growth stimulation through the facilitation of nutrient feeding to hair follicle by the VEGF- induced angiogenesis.

LA Science:

CG-Keramin 2 - Reduce and prevent lines and wrinkles by actively generating new skin cells. - Refine texture glides effectively and light up skin. - Delivery of CG-Keramin2 to the base of the follicles which helps strengthen hair while stimulating hair follicles to produce strong hair shaft.

CG-IDP2 - Strengthen skin elasticity by inducing the synthesis of collagen and elastin. - Involve in normal skin growth,healing and wound repair. - Reduce and prevent lines and wrinkles by actively generating new skin cells.

Prohairin B4 - Increase cell growth and migration. - Promote hair growth by activating the stem cells of hair follicle. - More stable and prolong action than native proteins.

Decopeptide-42 Can't find this one on Caregen site, it's possible they meant oligopeptide-42

CG-Fibramin (oligopeptide-42) - Strengthen skin elasticity by inducing the synthesis of collagen and elastin. - Involve in normal skin growth, healing and wound repair. - Promote hair growth and inhibit depigmentation of hair. - Help blood circulation in the scalp and revitalizing hair follicles.

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Re: DermaHeal discount(15%) code

Post by intricate1 » Fri Sep 11, 2009 11:25 pm

Good with rogain foam is making my hair thicker

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Re: DermaHeal discount(15%) code

Post by intricate1 » Sun Sep 13, 2009 8:47 am

Improving Hair Growth with Skin Remodeling Copper Peptides

Loren Pickart PhD

When we are young, our hair is thick, well-pigmented and grows rapidly on our head. But with the passage of time, the hair thins or vanishes, growth slows, and becomes grayer. While the search for methods to restore healthy, younger hair is ancient, the reality is that, even today, in the era of minoxidil (Rogaine) and finasteride (Propecia), all existing therapies give at best a marginal restoration of hair health.

Skin remodeling copper peptides, or SRCPs for short, are the latest candidate being tested for the improvement of hair health. What are SRCPs? They are types of copper peptides that are based on a human copper peptide complex called glycyl-l-histidyl-l-lysine:copper (II) or GHK-Cu for short. See Figure 1.

Figure 1 Legend: Solution structure of GHK-Cu
Last edited by intricate1 on Sun Sep 13, 2009 8:52 am, edited 1 time in total.

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Re: DermaHeal discount(15%) code

Post by intricate1 » Sun Sep 13, 2009 8:51 am

GHK-Cu is a normal component of human blood plasma, urine, and saliva. (1) It is increasingly being used in products sold for reversing the effects of aging on human skin. SRCPs are defined as having actions similar to GHK-Cu which include anti-inflammatory effects, skin repair actions, and the ability to increase the size of hair follicles. It should be emphasized that not all copper-peptides have such positive actions; indeed, some copper-peptides can inhibit these effects. (2-4)

Causes of Hair Thinning and Loss of Vitality

Before discussing the use of SRCPs on hair, it is best to first focus on the causes of hair thinning and loss in healthy humans. These causes are more diverse than generally realized although most attention has been focused on blocking the actions of DHT (dihydrotestosteone). For example, most theories of hair loss and thinning hair have focused on the metabolic actions of DHT, but in reality, other factors can also induce or modulate these effects. So it is best to consider each factor that influences hair growth separately.

DHT – The actions of the androgens testosterone and DHT are major factors in scalp hair growth and male pattern baldness (androgenetic alopecia). Such androgens also stimulate axillary, pubic and beard hairs to grow. However, hairs such as eyebrows and eyelashes are not regulated by androgens. Testosterone is enzymatically converted by 5-AR to DHT in the hair follicle and DHT is thought to be the major factor in male pattern baldness.

But many men have high testosterone metabolite levels but never suffer hair loss. The ultimate factor in hair loss appears to be not DHT itself, but damage to the hair follicle. A recent study of 3,000 individuals found no link between baldness and the genes (5-alpha reductase) controlling the the production of testosterone metabolites. (5,6) Some researchers are of the opinion that if follicular health is improved or maintained, it is possible that hair loss can be reversed or minimized.

Miniaturized follicles – At age 15, hair follicles actively produce thick, heavy terminal hair for about 3.6 years during the anagen phase then shrink during the dormant telogen phase for about 4 months. As we age, the follicle's anagen phase progressively shortens while the telogen phase lengthens. The net result is a progressive shrinkage of follicle size during the anagen phase and this produces thinner, slower growing hair. (5,6) Hair conditioners are used to thicken the hair shaft with fats and proteins to give the appearance of fuller, more-youthful hair.

Increase in length of dormant follicle phase – While this change is usually attributed to DHT actions, other factors such a damage caused by excessive heat, coloring agents, and relaxers may also produce follicle damage that results in less functional follicles.

Inadequate follicle microcirculation – The synthesis of new hair necessitates a very high nutrient flow to the follicle bulb. Morphological studies often observe a markedly diminished capillary blood supply in aged, miniaturized follicles. This alone may be the cause of follicle miniaturization and inadequate hair syntheses. (5-7)

Inflammation around follicles – Many dysfunctional follicles appear to have an auto-immune inflammation around the follicle. It has been proposed that follicular inflammation is the final step in the sequence of events that ultimately produces inactive follicles that are incapable of producing thick, terminal hair. (5-7)

Decreased subcutaneous fat layer – The layer of fat at the base of the skin, also known as subcutaneous adipose tissue or colloquially called “baby fat”, diminishes with age. Researchers have noted the accumulation of this fat around healthy follicles that are vigorously growing hair, and its relative lack in around dormant follicles, and have postulated that these fat cells serve a supportive function for the hair follicle. Conditions that inhibit hair growth such as chemotherapy or starvation, also decrease the subcutaneous fat layer (5-7).

Damage from relaxers, excessive heat, coloring agents and dyes – Numerous common procedures damage scalp health and hair follicles. Scalp damage from relaxers, permanents, color cosmetics with their organic dyes and metallic salts, and excessive heat from blow dryers and hot oil treatments that can literally boil the follicles, all can combine to damage the hair follicle and reduce hair growth. This is often most noticeable in women as a decrease or loss of eyebrows and eyelashes by age 40.

Lack of sulfur donors – Hair is composed of 35% sulfur containing amino acids. Only feathers in birds have similar levels of such amino acids. Nutritional surfer supplements such as MSM (methyl sulfonyl methane) have long been used to improve the hair coats of racehorses and are increasingly being used to improve hair health in humans.

Graying of hair – The hair colors are produced in pigment cells in the follicles. The amino acid tyrosine is converted by the copper-containing enzyme, tyrosinase, into black pigments called melanin or eumelanin and a reddish pigment, produced by a separate gene, called heomelanin (or sometimes called phaeomelanin). In most persons, hair color slowly decreases with age and may vanish to produce white hair in the elderly.

Excessive hair cutting – Dr. George Michael (founder of the George Michael Long Hair Clinics) emphasized that longer hair is healthier hair. It is possible that hair follicles require some tension produced by the weight of a heavy hair shaft in the same manner that muscles and bones whither when not stressed and exercised. Michael remembered that, in the Russia of his youth, women in their sixties often had healthy, waist-length hair. Later, when he worked in New York City, he found that virtually no women of this age possessed such healthy hair.

SRCPs to Stimulate Hair Growth

One of the more exciting developments in skin research in recent years is the finding that hair follicles are the source of stem cells for the skin. (8,9) But long before these discoveries that linked hair follicles and skin repair, I had observed that, after treating skin wounds with GHK-Cu, that there was a profound enlargement of the hair follicles of the skin at the wound edge. To develop these discoveries for commercial uses, in 1985 I started a company called ProCyte. Further work with radioisotopes in mice indicated that the SRCP was present at the site of injection for only about 30 seconds before being cleared from the area. This meant that a very brief exposure of the follicle to the SRCP was sufficient to produce an increase in hair follicle volume of 4 to 8-fold and increased hair growth within 12 days.
See Figure 2.

Figure 2 Legend. A 25 day-old mouse was shaved and injected intradermally in three spots with a SRCP. Twelve days later, there was a very strong stimulation of hair growth at the injection sites.



Further work by Steven Lovejoy (University of Washington) and myself found that the chemical addition of fat-like molecules, such as fatty acids or hydrophobic amino acid residues, to GHK-Cu, resulted in an intensified follicle enlargement action and more strongly stimulated the rate of hair growth in young mice. Even in undamaged mouse skin, one intradermal injection of the SRCPs induced accelerated hair growth after twelve days. Work with radioisotopes indicated that the SRCPs was present at the site of injection for only about 30 seconds before being cleared from the area. (10)

These discoveries were later verified and extended by Hideo Uno at the University of Wisconsin. Uno had written The UpJohn Company's textbook for physicians when Rogaine (minoxidil) first was marketed. Using hair growth models in mice and rats, Uno found that SRCPs convert fine, short vellus hairs into thicker pigmented terminal hairs.

Uno studied the details of hair stimulation by SRCPs in C3H mice and “Fuzzy” rats by 1) phototrichogram, 2) folliculogram (micro morphometric analysis), and 3) the rate of DNA synthesis in the follicular cells. He found that in C3H mice, the SRCPs stimulated of the follicular cell proliferation, resulting in an enlargement of the anagen follicles from vellus types that produce small, thin hair to terminal follicles that produce thick, long hair. type The SRCPs also maintained follicles in the anagen phase longer. In Fuzzy rats, a genetic strain that has only short vellus hair, the SRCPs had the effect of enlarging the small vellus follicles. (11-12).

Also of interest were studies by Awa and Nogimori of Kaken Pharmaceuticals reported, that in mice, pretreatment with SRCPs blocked hair loss induced the cancer chemotherapy drugs cytosine arabinoside and doxorubicin. If mice were first treated with chemotherapeutic drugs to induce hair loss, subsequent treatment with SRCPs accelerated the recovery of lost hair. (13)

Bernard Kalis (University of Reims) was the first to demonstrate that SRCPs also had positive actions on hair follicle functions in humans. His studies used phototrichogram analysis that found SRCPs caused a greater proportion of human follicles to switch from the dormant telogen state into the hair-growing anagen state. (14) A later placebo-controlled, three-month study in male humans found a SRCP (Ala-His-Lys: copper(II)) in a product called Tricomin increased the terminal hairs and was 32% more effective than the control group that used 2% minoxidil in this study. (15)

Hideo Uno has commented that while minoxidil primarily stimulates new vellus hair growth, the SRCPs are more effective in the conversion of vellus hair into terminal hairs and suggested that the combined use of minoxidil and SRCPs would have a synergistic actions and be most effective. See Figure 2.

Note – Figure 3 is self explanatory about the actions of minoxidil and SRCPs.



SRCPs and Hair Transplantation

Another developing use for SRCPs is their use to improve human hair transplantation. GraftCyte, a copper peptide product sold by ProCyte, when used in the post-operative regimen results in faster healing of transplants and earlier regrowth of the hair shafts. GraftCyte is sprayed on the wound area after transplants. Controlled studies by Perez-Meza et al found that the GraftCyte system provided enhanced healing of the transplanted follicle and less post-operative hair shedding along with a more immediate hair growth. Patients see new hair growth in 6 weeks, versus the normal 10 to 14 weeks of other procedures. The normal skin crusting after transplantation has been reduced from 10 to 14 days to 5 days in most cases. (16).

A second controlled study of Graftcyte by Gary Hitzig on 30 hair transplant patients found that Graftcyte reduced percent of patient with shedding of transplanted hair from 30% with saline to 10% with Graftcyte. The time to healing of the transplant wounds using Graftcyte and Dr. Hitzig's procedure was 10-14 days with saline and 5-10 days with Graftcyte. Regrowth of new hair from the transplants occurred in 6-8 weeks with saline and 4-6 weeks with Graftcyte. Patient satisfaction after transplantation rose from 80% to 95%. (17) Graftcyte can be obtained from www.procyte.com.

Improving General Hair Vitality with SRCPs

While the above studies were encouraging, it is also apparent that the SRCPs are not miracle hair growth therapies. A more important future use of SRCPs may as a regular scalp treatment or hair tonic, used once or twice weekly, for the general improvement of hair and scalp health. SRCPs have numerous actions that may improve hair health. See Figure 4. These include:

Note – Figure 4 is self explanatory about aging and follicle damage.



Reduce DHT formation in the hair follicles – 5-alpha reductase exists in 2 forms; type 1 which function in hair follicles and type 2 which acts in prostate tissue. Follicle damaging DHT is produced in the hair follicles. Propecia (finasteride) inhibits 5-AR throughout the body and improves hair growth. But it works best on the type 2 form, and is best suited for for controlling prostate enlargement. It also must be administered by pills that spread the drug throughout the body. However, increased copper ions in the skin is better at inhibiting the type 1 5-AR that damages hair growth. Sugimoto et al (Sugimoto 1995) found that copper (II) ions could give up to a 90% inhibition of type 1 5-AR. at At 0.12 micrograms copper ion per milliliter, there was a 50% reduction in activity of type 1 alpha reductase but copper (II) ions were 10-fold less active on inhibiting the type 2 prostate type. Thus, copper ions are more specific inhibitors of 5-AR than finasteride. (18)

Human transdermal studies have found that concentrations up to 0.50 micrograms of copper ion can be introduced into the skin with SRCPs without skin irritation. For comparison, the blood plasma copper level is approximately 1 milligram per milliliter.

Improve Microcirculation to Hair Follicle – Hair follicles have very high rates of metabolic activity. However, morphological studies of aged follicles often find an inadequate capillary circulation and some have suggested that the resultant lack of nutrient flow may be a causative factor in the thinning of hair shafts with age. SRCPs have angiogenic activity may possibly correct this problem. (2)

Protective Anti-inflammatory Actions – The final event in the sequence of degenerative changes that produce involuted non-functional hair follicles are tissue-damaging auto-immune inflammatory and free radical reactions around the follicle. SRCPs may reduce such effects since they block both the inflammatory actions of both interleukin 1and TGF-beta-1 actions in inflammation. (19-21) Also during tissue injury, the release of ferrous iron from ferritin increases the formation of tissue-damaging free radicals, but SRCPs block the release of iron from ferritin. Finally, copper, zinc superoxide dismutase (SOD) is normally only about 50% activated due to a lack of copper in the protein. SRCPs can supply additional copper to SOD and increase its anti-oxidant effectiveness. (22)

Autoimmune damage causing hair loss exists in conditions such as alopecia areata, diabetes, vitiligo, certain types of thyroid disease, and pernicious anemia. The treatment for these conditions is usually a short course of any cortisone-type drugs which often restores hair growth. But cortisone injections into the bald spots bring the hair back only temporarily. The problem is that costicosteroids inhibit skin repair and often produce and thinner, less functional skin that is less able to support hair follicle functions. In studies on nickel allergy patients, Zhai et al wrote that SRCPs to be as potent as cortisone in reducing redness and inflammation while also stimulating skin repair in nickel allergy patients. (23)

Enhancement of the skin's subcutaneous fat layer and thickening of the scalp – During human aging, there is a thinning of the scalp. Part of this is due to a diminishment of the scalp's subcutaneous fat layer that surrounds the hair follicles diminishes with age. Pathologists have noted that large subcutaneous fat cells are associated with large, healthy hair follicles and are postulated to provide nutritional support to the follicles. Conditions that cause hair loss such as cancer chemotherapy are associated with a sharp decrease in the volume of subcutaneous fat cell. SRCPs increase both the hair follicles size and the amount of subcutaneous fat. (24)

SRCPs also help increase skin thickness by increasing the dermal levels of collagen, elastin, and the water-holding proteoglycans and glycosaminoglycans. (2-3)

Repair of Damaged Scalp – Hair loss, especially in women, may often be caused by scalp damage from relaxers, permanents, coloring chemicals, and excessive heat from blow dryers and hot oil treatments. This is often evident in women who have seriously thinned eyebrow by age 40 after decades of application of color cosmetics. SRCPs might be used after various hair procedures to speed repair of scalp damage.

Reduce Graying of Hair - Hair becomes gray with age but the speed that this happens may depend on the adequacy of available copper in the scalp. Melanin and other hair pigments are produced from the amino acid tyrosine by the action of tyrosinase, a copper-containing enzyme. Additional scalp copper might slow this graying process and our clients at Skin Biology have often reported the re-pigmentation of gray hair after using our Folligen products.

Future Development of SRCPs for Hair Health

While research between 1983 and 1991 established the potential uses of SRCPs, it also became apparent that much more effective and stable SRCPs were needed to develop practical and truly effective products. Therefore, in 1994, I founded Skin Biology to develop improved SRCPs.

Previously when I was at ProCyte, I had used chemical modifications of molecules to create more-active SRCPs. But the problem with this chemical approach is that the human body often has difficulty metabolizing alien molecules. Peptides from soy protein digests have a long history safe use in products ranging form solutions used for intravenous alimentation to hair conditioners used to add body to hair. At Skin Biology, we isolated a special from the soy protein digests. When this fraction when chelated to copper (II) produces a very strong stimulation of hair growth in standard models in mice, strongly stimulated skin rebuilding, and had anti-inflammatory actions. (23,25-28)

To enhance the uptake of SRCPs into the skin and hair follicles, we focused on natural penetrating agents such as emu oil or squalane from olives to push more SRCP into the skin. We also are testing the use of encapsulating the SRCPs in newer types of advanced liposomes to increase potency. Several products based on this new technology are being test marketed at www.folligen.com.

There is also the possibility that some variant of SRCPs could be used to induce hair follicle multiplication. Often during studies in mice, we have observed what appeared to be an increased production and density of hair follicles. This effect was often observed during skin transplantation experiments and may more complex than the more simple enlargement of hair follicle size that we most often observed. See Figure 5. Dermatological dogma is that hair follicles never multiply but, in the era of stem cells and DNA cloning, anything is possible.

Figure 5. Increased hair follicle density in transplanted mouse full thickness skin graft treated with SRCPs.

 

References

1. Pickart, L. A tripepeptide in human serum that promotes the growth of hepatoma cells and the survival of normal hepatocytes, Ph.D. thesis, Univ. of California, San Francisco, 1973

2. Pickart, L. , Copper Peptides for Tissue Regeneration, Speciality Chemicals 2002 (October) pages 29-31

3. Pickart, L., Reversing Skin Aging with Copper Peptides, Body Language Dermatol. 2003 (April) pages 12-13

4. Pickart, L., Copperceuticals and the Skin, Cosmetics & Toiletries 2003; 118, 24-28.

5. Ellis, J.A., Stebbing, M., Harrap, S.B., Genetic analysis of male pattern baldness and the 5-alpha reductase genes, J Invest Dermatol 1998; 110, 849-853

6. Uno, H., The Histopathology of Hair Loss (Publisher: The UpJohn Company, Kalamazoo, MI) 1988

7. The Molecular and Structural Biology of Hair (Stenn K.S., Messenger A.G., and Baden H.P, (eds). Ann NY Acad Sci; New York: New York Academy of Sciences) 1991.

8. Jahoda, C.A., Whitehouse, J., Reynolds, A.J., Hole, N., Hair follicle dermal cells differentiate into adipogenic and osteogenic lineages. Exp Dermatol. 2003; 12, 849-859.

9. Lavker, R.M., Sun, T.T., Oshima, H., Barrandon, Y., Akiyama ,M., Ferraris, C., Chevalier, G., Favier, B., Jahoda, C.A., Dhouailly, D., Panteleyev, A.A., Christiano, A.M., Hair follicle stem cells, J Investig Dermatol, 2003; 8, 28-38

10. Pickart, L., New metal peptide complexes and derivatives used for stimulating growth of hair in warm-blooded animals, especially humans, US Patent 5,120,831; Compositions for stimulating hair growth containing cupric complexes of peptide derivatives including. glycyl-l- histidyl-l-lysine n-octyl ester. US Patent 5,177,061; New glycyl-histidyl-lysyl copper compounds used in stimulating hair growth; US Patent 5,214,032; Metal-peptide compositions and methods for stimulating hair growth, US Patent 5,550,183

11. Trachy, R., Fors, T.D., Pickart, L. Uno, H. The hair follicle stimulating properties of peptide copper complexes. Results in C3H mice. Ann N Y Acad Sci 1991;642, 468-469

12. Uno, H., Kurata, S. Chemical agents and peptides affect hair growth. J. Invest Dermatol 1993; 101, 143S-147S

13. Awa, T., Nogimori, K., Trachy, R. Hairloss protection by peptide-copper complex in animal models of chemotherapy-induced alopecia. J Dermatol Sci 1995; 10, 99-104

14. Trachy, R., Patt, L., Duncan, G., Kalis, B., Phototrichogram Analysis of Hair Follicle Stimulation: A pilot clinical study with a peptide-copper complex, in: Dermatological Research Techniques, (Edited by H.I. Maibach, CRC Press), 1996, pp-217-226

15. Press release, Procyte Corporation, 1997

16. Perez-Meza, D., Leavitt, M., Trachy, R. Clinical evaluation of GraftCyte Moist Dressing on hair graft viability and quality of healing. Inter J Cos Surg 1998; 6, 80-84

17. Hitzig,G. Enhanced healing and growth in hair transplantation using copper peptides, Cosmetic Dermatol 2000 (June) ; 13, 18-21

18. Hitzig,G. Enhanced healing and growth in hair transplantation using copper peptides, Cosmetic Dermatol 2000 (June) ; 13, 18-21

19. Pickart, L., New glycyl-histidyl-lysine ester copper complex compounds with anti-inflammatory and superoxide dismutase activity useful for enhancing wound healing. US Patent 4,877,770; New anti-oxidative and anti-inflammatory metal peptide complexes - containing. glycyl histidyl and lysine residues used to enhance or restore resistance to oxidative or inflammatory damage. US 5,118,665

20. Vinci C., Caltabiano V., Santoro A.M., Rabuazzo A.M., Buscema M., Purrello R., Rizzarelli E. Copper addition prevents the inhibitory effects of interleukin 1-beta on rat pancreatic islets. Diabetologia. 1995; 38:39-45

21. McCormack MC, Nowak KC, Koch RJ. The effect of copper tripeptide and tretinoin on growth factor production in a serum-free fibroblast model. Arch Facial Plast Surg 2001; 3:28-32

22. Miller D.M., DeSilva D., Pickart L., Aust S.D. Effects of glycyl-histidyl-lysyl chelated Cu(II) on ferritin dependent lipid peroxidation. Adv Exp Med Biol 1990; 264: 79-84
23. Zhai H., Chang Y.C., Singh M., Maibach H.J. In vivo nickel contact dermatitis: human model for topical therapeutics. Contact Dermatitis 1999; 40: 205-208

24. Pickart, L., Skin treatment composition comprises GHL-CU or derivatives for improving skin health, increasing subcutaneous fat, dermal thickness and density. US Patent 5,135,913

25. Pickart, L., Tissue protective and regenerative compositions, US Patents 5,382,431, US 5,888,522, US 5,554,375

Note on reference 25 – The title of all three patents is the same. But they make different claims on the same text.

26. Zhai H., Poblete N., Maibach H.J. Stripped skin model to predict irritation potential of topical agents in vivo in man. Inter J Dermatol 1998; 37: 386-389

27. Zhai H., Leow Y.H., Maibach H.R., Human barrier recovery after acute acetone perturbation: an irritant dermatitis model. Clin Exp Derm, 1998: 23: 11-13

28. Zhai H., Leow Y.H., Maibach H.R., Sodium lauryl sulfate damaged skin in vivo in man: a water barrier repair model. Skin Res Tech, 1998: 4: 24-27

29. For more references, see www.skinbiology.com/copperpeptideregeneration.html
Figures

Figure 1 Legend – Solution Structure of GHK-Cu

Figure 2 Legend. A 25 days old mouse was shaved and injected intradermally in three spots with a SRCP. Twelve days later, there was a very strong stimulation of hair growth at the injection sites.

Figure 3 is self explanatory about the actions of minoxidil and SRCPs.

Figure 4 is self explanatory about aging and follicle damage.

Figure 5 Legend - Increased hair follicle density in transplanted mouse full thickness skin graft treated with SRCPs. Top photo is graft infused with saline. Bottom photo is graft infused with SRCPs.

Note – Figure 5 was scanned at 400 dpi but then converted to a jpeg image. But is still should produce a good picture.


 
 
 

Interview with Loren Pickart PhD

- Mr. Pickart, am I right that you were the first scientist who started research on Copper-Peptides and there was nothing known about them before?

- I would not say that proteins associated with copper were completely unknown. Chemists had been investigating the ability of copper to make complexes with some peptides. And there is a lot of research on copper and enzyme superoxide dismutase. But this molecule, the model of which I'm holding now (Seen Here), was unknown to scientists.

It all happened in 1970s when I was working at the University of California at San Francisco. It was time of great belief in medicine. Many scientists wanted to do big things, such as fighting cancer. I decided to find the way to reverse human aging.

We worked with blood cells and discovered that young cells contained some Copper-Peptide complex. We found out, that old cells lasted longer if we supplied them with this peptide complex. But it took us 15 years to understand how they work. Now we know that Copper-Peptides work as a restorative signal in skin, bones, and hair follicles. And it is possible that they work the same way in other tissues.

- So they work as growth factors?

- Not exactly. Let us look at wound healing. After damage, there are mostly destructive and sterilizing processes involving free radicals. Then cells begin to release transforming growth factor TGF-beta-1 that stimulates scar formation. But damaged tissue also releases Copper-Peptides. At some point their concentration reaches the level where they suppress TGF-beta-1 production and block oxidation.

- I have read that free radicals could be a restorative signal and because of this too much antioxidants might delay wound healing.

- I believe in good oxidation. You can accelerate wound healing by applying oxidizing agents first and Copper-Peptides second.

- In your article you are saying that Copper-Peptides work as antioxidants and anti-inflammatory agents; they also inhibit scar formation, stimulate angiogenesis, attract macrophages to wound, stimulate hair follicles, speed up both collagen destruction and new collagen synthesis...

- Yes, that's correct. They remodel skin, you may say that they turn off destruction and turn on reparation.

- It is hard to believe that one molecule can be so powerful.

- We hardly could believe it too. But numerous other laboratories all over the world extended our observations. French scientists found that Copper-Peptides stimulate nerve growth, scientists from National Cancer Institution researched angiogenesis, scientists from Utah investigated antioxidant capacity of this molecule and so on.

- We keep talking about medical use, but now they are used in cosmetic industry.

- Yes, initially we developed these products for medical use, but physicians don't like trying new inventions; they prefer well-known remedies. Besides, the procedure of drug approval is ridiculously complicated in USA. It takes years and you have to spend a fortune. It is much easier to get approval for cosmetic products, and women love to explore new cosmetics. I can assure you, that many cosmetic products already contain the medicine of the future, because their developers do not want to bother with drug approval. But I agree that unlike drugs, cosmetic products should be perfectly safe. We tested Copper-Peptides and didn't find any toxicity, any side effects. They are safe, and they are meant to be safe, because they are found in human body and they don't modify any physiological processes in skin. They protect skin and give the signal to restoration. Don't you think it is perfect role for cosmetic ingredients?

- You mean that there is no risk of scar formation or inflammation even if people use high concentrated products?

- On the contrary, Copper-Peptides prevent scars and inflammation. Some women using our products report disappearance of stretch marks and scars. We have very good testimonials, especially from middle-aged women. Usually they buy one or two products for start, then come back for more, and then start to recommend them to all their friends and relatives. Their praises keep us going. (Read Their Testimonials Here)

- It seems that your product affects the skin physiology after all. But FDA still requires cosmetic products to be inert in skin.

- There are no such things as inert cosmetic ingredients. All substances that we put on our skin, such as Vaseline and other emollients (even plain water) affect skin in some way. And people in FDA understand this. They also understand that modern people want cosmetics to improve skin, to make it better. I have no doubt that the definition of cosmetics will be changed soon.

- Today many cosmetic companies make cosmetics using your Copper-Peptides. Do you believe they use efficient concentrations of Copper-Peptides?

- Unfortunately many cosmetic companies just don't care. They want a popular ingredient on the label and that is all. But some companies make very good products and spend a fortune on testing. It is not only a matter of concentration, it is important to know how Copper-Peptides will behave in a complex mixture, and how a technical process will affect them. That is why dermatological testing of finished products is so important.

- It seems for majority of cosmetic manufacturers it is still easier to make fake claims rather than develop potent cosmetic products?

- Unfortunately it is true. But this situation is changing now. The more great cosmetic products come to the market, the closer the future in which only efficient cosmetics will be profitable.

- As I understand, your company does a very little manufacturing, and your main occupation now is still science of reversal of skin aging. But don't you ever dream to be famous with your own cosmetic line?

- Yes, I have been thinking about this a lot. But I prefer to be a scientist. Manufacturing and promotion of new cosmetics is a tough business. I'm 65 years old and I want to enjoy life.

 

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Copyright 2008 Dr. Loren Pickart

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intricate1
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Re: DermaHeal discount(15%) code

Post by intricate1 » Sun Sep 13, 2009 6:45 pm

shedding only when applying, healthier scalp, some regrowth on the temples, good combo with rogain foam. But from reading these peptides have been around for a while, good for maintaining what you have.

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Re: DermaHeal discount(15%) code

Post by intricate1 » Thu Sep 17, 2009 1:01 pm

Anybody else have good results or amm I the only one

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Re: DermaHeal discount(15%) code

Post by 1..... » Thu Sep 17, 2009 1:17 pm

good to hear intricate. does it make your hair feel thicker like the AGHC? And how many hairs are you shedding per day?

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Re: DermaHeal discount(15%) code

Post by intricate1 » Thu Sep 17, 2009 3:07 pm

Yes similar to how aghc felt after application. Hair darker, thicker, healthier, better scalp condition. I don't know if it's regrowth or vellous tiny hairs are terminal again. good with rogain foam I stated with the foam cause I need a good thickener for crown and I read what pickart wrote about peptides. So I wouldn't call it a cure but it delivered what aghc couldn't and stole. If you have a full head of hair it is great for maintainance. They say use it for 3 month for full results but I'm only 24 days in so maybe I'll even have better results

takin: tocotrienol vitamine e 125 ml at night of unique brand Vitamine shoppe 38$( just started). applying serum and shampoo at night
rogain and light nourish shampoo in the morning

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Re: DermaHeal discount(15%) code

Post by intricate1 » Thu Sep 17, 2009 3:10 pm

Shedding Only applying serum. I don't touch my hair when it's wet and I let it air dry, no shed while I apply shampoos or the rogain foam

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Re: DermaHeal discount(15%) code

Post by Anxious1 » Thu Sep 17, 2009 3:52 pm

can u be more specific about the regrowth u r experiencing after 24 days?

how do u split up the results attributed to the dermaheal, and results attributed to the minox?

i.e. how do u know the vellis hairs isnt from the minoxidil?

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Re: DermaHeal discount(15%) code

Post by ChuckP » Thu Sep 17, 2009 4:09 pm

I said awhile ago I have been using shampoo and serum for close to 3 months and it has been making my hair look worse.

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Re: DermaHeal discount(15%) code

Post by intricate1 » Thu Sep 17, 2009 9:49 pm

I can't say for sure if regrowth is from derma and not minox, but I did see my temples get smaller before I started using minox all over my head. It could have been my vellus hair getting thicker. I'm going to use it longer minox and vitamine e and report back

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Re: DermaHeal discount(15%) code

Post by SW2 » Wed Sep 23, 2009 7:58 am

intricate - are you using dermaheal once or twice a day?

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Re: DermaHeal discount(15%) code

Post by intricate1 » Wed Sep 23, 2009 10:34 am

I use it once, I havnt used it for 4 days and shedding is back to full mode I'm waiting for my second order. It has to be used constantly for a healthier hair. At least they don't lie and say it's a one time treatment and charg 200 for it like a&g

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Re: DermaHeal discount(15%) code

Post by intricate1 » Wed Sep 30, 2009 6:56 pm

It has been about over a month now since iv used it. I had t take a five day break to receive my second shipment. My shedding subsided on the first round but agin it's shedding when applying, I'm gonna do it every other day from now instead of everyday. I think I'm shampooing hair two many times 2-3 times a day hair does not look healthy. Taking msm,biotin,tocotrienol,fish oil,vitamine a & c. I will try this product two more shipments then will take a breake and use DERMATOPOIETIN® stuff In about two month or terminal 1-2

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Re: DermaHeal discount(15%) code

Post by intricate1 » Wed Sep 30, 2009 7:01 pm

Any other update ?

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Re: DermaHeal discount(15%) code

Post by jksl » Wed Oct 07, 2009 4:35 pm

Can other dermaheal users come in to say something about their results? I'm looking to try out a minox-free topical.

Intricate1, how much does this stuff cost you a month?

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Re: DermaHeal discount(15%) code

Post by intricate1 » Wed Oct 07, 2009 4:51 pm

jksl wrote:Can other dermaheal users come in to say something about their results? I'm looking to try out a minox-free topical.

Intricate1, how much does this stuff cost you a month?
I now use every other day and use emu oil on the off days, 65$ a bottle 1 botlle or so a month. It's not dose dependent so it depends on how long your hair is. Yeah Non of the forums have anything to say as far as results. Can you please report back it a good product

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Re: DermaHeal discount(15%) code

Post by jksl » Wed Oct 07, 2009 5:15 pm

intricate1 wrote:
jksl wrote:Can other dermaheal users come in to say something about their results? I'm looking to try out a minox-free topical.

Intricate1, how much does this stuff cost you a month?
I now use every other day and use emu oil on the off days, 65$ a bottle 1 botlle or so a month. It's not dose dependent so it depends on how long your hair is. Yeah Non of the forums have anything to say as far as results. Can you please report back it a good product
Thanks for the reply. Are you using the DermaHeal Stem C’Rum HL serum or the regular HL serum? Do any of them contain nokkin?

Is nid still doing the group buys from caregen?

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Re: DermaHeal discount(15%) code

Post by intricate1 » Wed Oct 07, 2009 6:09 pm

From what I know the hair concentrating serum is their latest one and best one that's what I'm using, I can't imagine all these peptides and growth factors are not that different, but I'm not sure. I wanna get dermapoetin and switch them up if it gets good reviews, get the shampoo lasts a while and it's good

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Re: DermaHeal discount(15%) code

Post by jksl » Thu Oct 08, 2009 10:22 pm

are you still using it every other day? Do you use it at night? Do you wash your hair before applying it? Do you keep the serum and shampoo in the refrigerator?

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Re: DermaHeal discount(15%) code

Post by intricate1 » Thu Oct 08, 2009 10:35 pm

I use it every other day or two days, I keep both in the fridge when i remember but u don't have to. I use it sparingly it last longer just make sure you saturate the thining/ balding areas. I do wash my hair with the shampoo and I always let my hair air dry before applying. Cause it's nanosome the absorbtion shouldn't be a problem

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Re: DermaHeal discount(15%) code

Post by MG63 » Mon Oct 19, 2009 1:25 pm

I've been using the serum since June 15, 2009. The fine hairs have converted to terminal hairs, resulting in thickening up on the crown and in the front. I used it every day for the first 3 months and then moved to every other day. Good product. !!!

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Re: DermaHeal discount(15%) code

Post by jksl » Mon Oct 19, 2009 9:04 pm

MG63 wrote:I've been using the serum since June 15, 2009. The fine hairs have converted to terminal hairs, resulting in thickening up on the crown and in the front. I used it every day for the first 3 months and then moved to every other day. Good product. !!!
I hope you're not being sarcastic. If you're not, then great! I need to use a decent topical soon. Looks like i'll be ordering this one. Gonna do it right now.

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Norwood Level: Norwood II
Have you had a hair transplant?: No
Treatment Regimen: A&G hair complex rogain nizoral

Re: DermaHeal discount(15%) code

Post by intricate1 » Mon Oct 19, 2009 10:56 pm

It's not a miracle but it does what it says ^

intricate1
Prolific Poster
Posts: 424
Joined: Wed Apr 29, 2009 4:46 pm
Hair Loss Type: Androgenetic Alopecia (Male Pattern Baldness)
Norwood Level: Norwood II
Have you had a hair transplant?: No
Treatment Regimen: A&G hair complex rogain nizoral

Re: DermaHeal discount(15%) code

Post by intricate1 » Tue Oct 20, 2009 7:30 am

Mg63 you laser before applying right? Has it almost filled your crown? And you don't use minox right?

MG63
Seasoned Poster
Posts: 93
Joined: Mon Jul 27, 2009 4:12 am
Hair Loss Type: Androgenetic Alopecia (Male Pattern Baldness)
Norwood Level: Norwood II
Have you had a hair transplant?: Yes
Treatment Regimen: Laser
Dermaheal
Crescina Stem Cell 500

Re: DermaHeal discount(15%) code

Post by MG63 » Wed Oct 21, 2009 11:20 am

I put it on 10 minutes before lasering. I've been using sinere nanominoxidil during the day for over a year. Per Dermaheal, the real changes did not show up until September, after 3 months of use. Patience is important. BTW - on the shampoos, I use Morocco Method shampoos in the evening before applying the dermaheal, they are excellent for cleaning the scalp. In the morning I use Revita.

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